Search: onr:"swepub:oai:DiVA.org:umu-79930" >
Left atrial remodel...
-
D'Ascenzi, Flavio
(author)
Left atrial remodelling in patients undergoing transcatheter aortic valve implantation : a speckle-tracking prospective, longitudinal study.
- Article/chapterEnglish2013
Publisher, publication year, extent ...
-
2013-07-14
-
Springer Netherlands,2013
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-79930
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79930URI
-
https://doi.org/10.1007/s10554-013-0265-zDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Aortic stenosis (AS) results in several left ventricular (LV) disturbances as well as progressive left atrial (LA) enlargement and dysfunction. Transcatheter aortic valve implantation (TAVI) reverses LV remodelling and improves overall systolic function but its effect on LA function remains undetermined. The aim of this prospective, longitudinal study was to investigate the effects of TAVI on LA structure and function. We studied thirty-two patients with severe symptomatic AS who underwent TAVI, using standard and 2-dimensional speckle-tracking echocardiography before, at 40-day and at 3-month follow-up. Following TAVI, mean transvalvular gradient decreased (p < 0.001). Both LA area index and LA volume index decreased at 40-day follow-up (16.2 ± 6.4 vs. 12.5 ± 2.9 cm(2)/m(2), and 47.3 ± 12.0 vs. 42.8 ± 12.5 mL/m(2), respectively, p < 0.05) and values remained unchanged at 3 months. The reduction of LA size was accompanied by a significant increase in global peak atrial longitudinal strain (14.4 ± 3.9 vs. 19.1 ± 4.7 %, p < 0.001) and in global peak atrial contraction strain (8.4 ± 2.5 vs. 11.0 ± 4.1 %, p < 0.05) at 3-month follow-up. LA stiffness measurements significantly decreased 3 months after TAVI (0.93 ± 0.59 vs. 0.65 ± 0.37, respectively, p < 0.001). Trans-aortic mean gradient change and pre-procedural LA volume were identified as predictors of global peak atrial longitudinal strain increase (β = -0.41, β = -0.35, respectively, p < 0.0001) while pre-procedural LA volume and trans-aortic mean gradient change as predictor of LA volume index reduction 3 months after TAVI (β = -0.37, β = -0.28, respectively, p < 0.0001). TAVI is associated with significant recovery of LA structure and function suggesting a reverse cavity remodelling. Such functional recovery is primarily determined by the severity of pre-procedural valve stenosis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Cameli, Matteo
(author)
-
Henein, MichaelUmeå universitet,Kardiologi(Swepub:umu)mihe0015
(author)
-
Iadanza, Alessandro
(author)
-
Reccia, Rosanna
(author)
-
Lisi, Matteo
(author)
-
Curci, Valeria
(author)
-
Sinicropi, Giuseppe
(author)
-
Torrisi, Andrea
(author)
-
Pierli, Carlo
(author)
-
Mondillo, Sergio
(author)
-
Umeå universitetKardiologi
(creator_code:org_t)
Related titles
-
In:The International Journal of Cardiovascular Imaging: Springer Netherlands29:8, s. 1717-17241569-57941875-83121573-0743
Internet link
Find in a library
To the university's database
- By the author/editor
-
D'Ascenzi, Flavi ...
-
Cameli, Matteo
-
Henein, Michael
-
Iadanza, Alessan ...
-
Reccia, Rosanna
-
Lisi, Matteo
-
show more...
-
Curci, Valeria
-
Sinicropi, Giuse ...
-
Torrisi, Andrea
-
Pierli, Carlo
-
Mondillo, Sergio
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
The Internationa ...
- By the university
-
Umeå University