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Improving signal de...
Improving signal detection in emission optical projection tomography via single source multi-exposure image fusion
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- Cheddad, Abbas (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Nord, Christoffer (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Hörnblad, Andreas (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Prunskaite-Hyyryläinen, Renata (author)
- Oulu Center for Cell-Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland
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- Eriksson, Maria (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Georgsson, Fredrik, 1971- (author)
- Umeå universitet,Institutionen för datavetenskap
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- Vainio, Seppo (author)
- Oulu Center for Cell-Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland
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- Ahlgren, Ulf (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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(creator_code:org_t)
- Optical Society of America, 2013
- 2013
- English.
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In: Optics Express. - : Optical Society of America. - 1094-4087. ; 21:14, s. 16584-16604
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- We demonstrate a technique to improve structural data obtained from Optical Projection Tomography (OPT) using Image Fusion (IF) and contrast normalization. This enables the visualization of molecular expression patterns in biological specimens with highly variable contrast values. In the approach, termed IF-OPT, different exposures are fused by assigning weighted contrasts to each. When applied to projection images from mouse organs and digital phantoms our results demonstrate the capability of IF-OPT to reveal high and low signal intensity details in challenging specimens. We further provide measurements to highlight the benefits of the new algorithm in comparison to other similar methods.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Annan medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Other Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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