Male serum Chlamydia trachomatis IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple

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Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi (author)

Male serum Chlamydia trachomatis IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple

Article/chapterEnglish2007

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2006-11-27
Wiley,2007
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LIBRIS-ID:oai:DiVA.org:umu-8162
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-8162URI
https://doi.org/10.1111/j.1365-2605.2006.00718.xDOI
https://gup.ub.gu.se/publication/79988URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: The objective of this study was to evaluate whether serum Chlamydia trachomatis immunoglobulin-A (IgA), IgM and C. trachomatis heat shock protein 60 (CHSP60) IgG are of additional value to C. trachomatis IgG regarding the impact on fecundity in infertile couples, and to relate C. trachomatis serum antibodies to semen characteristics, diagnoses and pregnancy outcome. METHODS: A total of 226 infertile couples, previously tested for C. trachomatis IgG, were tested for C. trachomatis IgA, IgM and CHSP60 IgG, and semen samples from all men were analysed. RESULTS: Chlamydia trachomatis serum IgA in men (but not in women) correlated with reduced chances of achieving pregnancy [p = 0.021, relative risk (RR) =0.65, 95% confidence interval (CI) 0.42-1.005] and in combination with C. trachomatis IgG the chance was further reduced (p =0.001, RR = 0.35, 95% CI 0.15-0.84). Chlamydia trachomatis serum IgA was also significantly correlated with reduced motility of the spermatozoa (-8.7%, p = 0.023), increased number of dead spermatozoa (+10.5%, p = 0.014) and higher prevalence of leucocytes in semen (+122%, p = 0.005), and in combination with C. trachomatis IgG positivity, there was also a decrease in sperm concentration (-35%, p = 0.033), the number of progressive spermatozoa (-14.8%, p = 0.029) and a rise in the teratozoospermia index (+4.4%, p = 0.010). CHSP60 IgG correlated with reduced motility (-5.6%, p = 0.033), and in the women to tubal factor infertility (p = 0.033), but no correlations of C. trachomatis serum IgM or CHSP60 IgG with pregnancy rates were found. CONCLUSIONS: Chlamydia trachomatis serum IgA in the male partner of the infertile couple has an additive value to IgG in predicting pregnancy chances, and serum IgA and IgG are associated with subtle negative changes in semen characteristics.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
Adult
Antibodies; Bacterial/blood
Chaperonins/*immunology
Chlamydia Infections/complications
Chlamydia trachomatis/*immunology
Female
Fertility/*physiology
Follow-Up Studies
Humans
Immunoglobulin A/*blood
Immunoglobulin G/*blood
Infertility; Male/immunology/microbiology/*physiopathology
Male
Microtubule-Associated Proteins/*immunology
Middle Aged
Multivariate Analysis
Pregnancy
Pregnancy Rate
Retrospective Studies
Semen/cytology/*physiology
Sperm Count
Sperm Motility/physiology
Spermatozoa/pathology/physiology
heat-shock proteins
tubal factor infertility
human spermatozoa
male-fertility
chain-reaction
antibodies
infection
sperm
hsp60
men

Added entries (persons, corporate bodies, meetings, titles ...)

Abramsson, LeifUmeå universitet,Urologi och andrologi (author)
Kumlin, UUmeå universitet,Virologi(Swepub:umu)urku0002 (author)
Liljeqvist, Jan-Åke,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xljanl (author)
Olofsson, J IUmeå universitet,Obstetrik och gynekologi (author)
Umeå universitetObstetrik och gynekologi (creator_code:org_t)

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In:International Journal of Andrology: Wiley30:2, s. 99-1070105-62631365-2605

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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