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Male serum Chlamydi...
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Idahl, Annika,1965-Umeå universitet,Obstetrik och gynekologi
(author)
Male serum Chlamydia trachomatis IgA and IgG, but not heat shock protein 60 IgG, correlates with negatively affected semen characteristics and lower pregnancy rates in the infertile couple
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2006-11-27
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Wiley,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-8162
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-8162URI
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https://doi.org/10.1111/j.1365-2605.2006.00718.xDOI
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https://gup.ub.gu.se/publication/79988URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: The objective of this study was to evaluate whether serum Chlamydia trachomatis immunoglobulin-A (IgA), IgM and C. trachomatis heat shock protein 60 (CHSP60) IgG are of additional value to C. trachomatis IgG regarding the impact on fecundity in infertile couples, and to relate C. trachomatis serum antibodies to semen characteristics, diagnoses and pregnancy outcome. METHODS: A total of 226 infertile couples, previously tested for C. trachomatis IgG, were tested for C. trachomatis IgA, IgM and CHSP60 IgG, and semen samples from all men were analysed. RESULTS: Chlamydia trachomatis serum IgA in men (but not in women) correlated with reduced chances of achieving pregnancy [p = 0.021, relative risk (RR) =0.65, 95% confidence interval (CI) 0.42-1.005] and in combination with C. trachomatis IgG the chance was further reduced (p =0.001, RR = 0.35, 95% CI 0.15-0.84). Chlamydia trachomatis serum IgA was also significantly correlated with reduced motility of the spermatozoa (-8.7%, p = 0.023), increased number of dead spermatozoa (+10.5%, p = 0.014) and higher prevalence of leucocytes in semen (+122%, p = 0.005), and in combination with C. trachomatis IgG positivity, there was also a decrease in sperm concentration (-35%, p = 0.033), the number of progressive spermatozoa (-14.8%, p = 0.029) and a rise in the teratozoospermia index (+4.4%, p = 0.010). CHSP60 IgG correlated with reduced motility (-5.6%, p = 0.033), and in the women to tubal factor infertility (p = 0.033), but no correlations of C. trachomatis serum IgM or CHSP60 IgG with pregnancy rates were found. CONCLUSIONS: Chlamydia trachomatis serum IgA in the male partner of the infertile couple has an additive value to IgG in predicting pregnancy chances, and serum IgA and IgG are associated with subtle negative changes in semen characteristics.
Subject headings and genre
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MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Urologi och njurmedicin hsv//swe
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MEDICAL AND HEALTH SCIENCES Clinical Medicine Urology and Nephrology hsv//eng
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Adult
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Antibodies; Bacterial/blood
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Chaperonins/*immunology
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Chlamydia Infections/complications
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Chlamydia trachomatis/*immunology
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Female
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Fertility/*physiology
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Follow-Up Studies
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Humans
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Immunoglobulin A/*blood
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Immunoglobulin G/*blood
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Infertility; Male/immunology/microbiology/*physiopathology
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Male
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Microtubule-Associated Proteins/*immunology
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Middle Aged
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Multivariate Analysis
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Pregnancy
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Pregnancy Rate
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Retrospective Studies
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Semen/cytology/*physiology
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Sperm Count
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Sperm Motility/physiology
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Spermatozoa/pathology/physiology
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heat-shock proteins
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tubal factor infertility
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human spermatozoa
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male-fertility
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chain-reaction
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antibodies
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infection
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sperm
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hsp60
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men
Added entries (persons, corporate bodies, meetings, titles ...)
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Abramsson, LeifUmeå universitet,Urologi och andrologi
(author)
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Kumlin, UUmeå universitet,Virologi(Swepub:umu)urku0002
(author)
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Liljeqvist, Jan-Åke,1954Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xljanl
(author)
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Olofsson, J IUmeå universitet,Obstetrik och gynekologi
(author)
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Umeå universitetObstetrik och gynekologi
(creator_code:org_t)
Related titles
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In:International Journal of Andrology: Wiley30:2, s. 99-1070105-62631365-2605
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