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Vitamin C transport...
Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort
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Duell, Eric J (author)
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Lujan-Barroso, Leila (author)
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Llivina, Claudia (author)
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Muñoz, Xavier (author)
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Jenab, Mazda (author)
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Boutron-Ruault, Marie-Christine (author)
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Clavel-Chapelon, Françoise (author)
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Racine, Antoine (author)
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Boeing, Heiner (author)
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Buijsse, Brian (author)
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Canzian, Federico (author)
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Johnson, Theron (author)
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Dalgård, Christine (author)
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Overvad, Kim (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Sánchez, Soledad C (author)
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Sánchez-Cantalejo, Emilio (author)
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Huerta, José-María (author)
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Ardanaz, Eva (author)
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Dorronsoro, Miren (author)
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Khaw, Kay-Tee (author)
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Travis, Ruth C (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Rafnsson, Snorri (author)
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Palli, Domenico (author)
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Sacerdote, Carlotta (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Grioni, Sara (author)
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Bueno-de-Mesquita, H Bas (author)
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Ros, Martine M (author)
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Numans, Mattijs E (author)
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Peeters, Petra H (author)
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansson, Mattias (author)
- Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Johansson, Ingegerd (author)
- Umeå universitet,Institutionen för odontologi
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Skeie, Guri (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Duarte-Salles, Talita (author)
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- Stenling, Roger (author)
- Umeå universitet,Patologi
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Riboli, Elio (author)
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Sala, Núria (author)
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González, Carlos A (author)
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(creator_code:org_t)
- 2013-06-05
- 2013
- English.
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In: Genes & Nutrition. - : Springer Berlin/Heidelberg. - 1555-8932 .- 1865-3499. ; 8:6, s. 549-560
- Related links:
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https://link.springe...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- Gastric cancer
- Vitamin C
- Antioxidants
- Genetic susceptibility
- SLC23A1
- SLC23A2
- Gastric cancer
- Vitamin C
- Antioxidants
- Genetic susceptibility
- SLC23A1
- SLC23A2
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Duell, Eric J
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Lujan-Barroso, L ...
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Llivina, Claudia
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Muñoz, Xavier
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Jenab, Mazda
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Boutron-Ruault, ...
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show more...
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Clavel-Chapelon, ...
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Racine, Antoine
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Boeing, Heiner
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Buijsse, Brian
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Canzian, Federic ...
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Johnson, Theron
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Dalgård, Christi ...
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Overvad, Kim
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Tjønneland, Anne
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Olsen, Anja
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Sánchez, Soledad ...
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Sánchez-Cantalej ...
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Huerta, José-Mar ...
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Ardanaz, Eva
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Dorronsoro, Mire ...
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Khaw, Kay-Tee
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Travis, Ruth C
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Rafnsson, Snorri
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Palli, Domenico
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Sacerdote, Carlo ...
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Tumino, Rosario
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Panico, Salvator ...
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Grioni, Sara
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Bueno-de-Mesquit ...
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Ros, Martine M
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Numans, Mattijs ...
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Peeters, Petra H
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Johansen, Dorthe
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Lindkvist, Björn
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Johansson, Matti ...
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Johansson, Ingeg ...
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Skeie, Guri
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Weiderpass, Elis ...
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Duarte-Salles, T ...
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Stenling, Roger
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Riboli, Elio
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Sala, Núria
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González, Carlos ...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Genes & Nutritio ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet
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University of Gothenburg