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Peripheral blood de...
Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation
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Maurer, D (författare)
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Fiebiger, S (författare)
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Ebner, C (författare)
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visa fler...
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Reininger, B (författare)
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Fischer, GF (författare)
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Wichlas, S (författare)
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Jouvin, MH (författare)
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- Schmitt-Egenolf, Marcus (författare)
- Department of Dermatology, University of Vienna Medical School, Austria
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Kraft, D (författare)
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Kinet, JP (författare)
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Stingl, G (författare)
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visa färre...
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(creator_code:org_t)
- American association of immunologists, 1996
- 1996
- Engelska.
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Ingår i: Journal of Immunology. - : American association of immunologists. - 0022-1767 .- 1550-6606. ; 157:2, s. 607-616
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Originally limited to basophils and mast cells, the spectrum of high affinity IgE receptor (Fc epsilon RI-bearing cells has expanded recently to include Langerhans cells, dermal dendritic cells (DC), monocytes, and eosinophils. As a result of studies on the distribution, structure, and function of Fc epsilon RI on APCs, we discovered a minor nonbasophil, nonmonocyte PBMC population that can bind IgE via Fc epsilon RI. This receptor occurs on the surface of these cells as a multimeric structure containing Fc epsilon RI alpha- and Fc epsilon RI gamma-chains but, unlike its counterpart on basophils, lacking Fc epsilon RI beta. Further experiments revealed that these Fc epsilon RI alpha gamma-expressing cells closely resemble peripheral blood DC by immunophenotype (HLA-DRhigh, HLA-DQhhigh; CD4+, CD11a+, CD32+, CD33+, B7/2 (CD86)+; CD11blow, CD14low, CD40low, CD54low, CD64low) and cell morphology. These features allowed us to isolate Fc epsilon RI-expressing DC from the peripheral blood and to investigate their immunostimulatory properties. We found Fc epsilon RI-positive DC to be efficient stimulators of both primary (allogeneic MLR) and Fc epsilon RI/IgE-dependent, secondary T cell responses at low cell numbers. Thus, Fc epsilon RI-expressing DC may not only amplify established type I allergic immune reactions but, unlike Fc epsilon RI-positive semiprofessional APCs, may be able to prime naive T cells to common and/or cryptic epitopes of IgE-reactive Ags.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- epidermal langerhans cells; antigen presentation; affinity receptor; lymphocytes-b; t-cells; internalization; localization
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Maurer, D
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Fiebiger, S
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Ebner, C
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Reininger, B
-
Fischer, GF
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Wichlas, S
-
visa fler...
-
Jouvin, MH
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Schmitt-Egenolf, ...
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Kraft, D
-
Kinet, JP
-
Stingl, G
-
visa färre...
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