Sub-second measurements of glutamate and other neurotransmitter signaling using enzyme-based ceramic microelectrode arrays

Hascup, E. R. (author)

Hascup, K. N. (author)

Talauliker, P. M. (author)

Price, D. A. (author)

Pomerleau, F. (author)

Quintero, J. E. (author)

Huettl, P. (author)

Gratton, A. (author)

Strömberg, Ingrid (author): Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)

Gerhardt, G. A. (author)

(creator_code:org_t)

2013-03-04
2013
English.
In: Microelectrode Biosensors (Part II). - Totowa, NJ : Humana Press. - 9781627033695 - 9781627033701 ; , s. 179-199

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

We have set out to develop a novel, implantable microelectrode array that has the capabilities to detect neurotransmitters with enhanced sensitivity, selectivity, and temporal sampling capabilities compared to other current technologies. We have shown that this device maintains recording performance during chronic measurements of extracellular neurotransmitter levels for at least 7 days postimplantation, single-unit neuronal activity for as long as 6 months, and provides enhanced biocompatibility compared to current technologies. As we continue to refine and improve our recording capability, we are able to incorporate the chronic microelectrode array technology into multimodal experimental paradigms, such as behavioral testing, pharmacological intervention (local and systemic), or combined measurements of neurotransmitter levels and neuronal activity (local field potential). Furthermore, the improvements made with the microelectrode technology discussed in this chapter have the potential to conduct longitudinal analyses that can benefit a wide range of translational efforts, including studies on learning and memory, aging, neurodegenerative disease progression, and traumatic brain injury neuropathology.

By the author/editor: Hascup, E. R.; Hascup, K. N.; Talauliker, P. M ...; Price, D. A.; Pomerleau, F.; Quintero, J. E.; show more...; Huettl, P.; Gratton, A.; Strömberg, Ingri ...; Gerhardt, G. A.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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