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The expression of a...
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Kadi, FawziUmeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology
(author)
The expression of androgen receptors in human neck and limb muscles : effects of training and self-administration of androgenic-anabolic steroids
- Article/chapterEnglish2000
Publisher, publication year, extent ...
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Springer Science and Business Media LLC,2000
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-83541
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83541URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-3518URI
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https://doi.org/10.1007/s004180050003DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Upprättat; 2000; 20070403 (andbra)
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The purpose of this study was to investigate the immunohistochemical expression of androgen receptors (AR) in human vastus lateralis and trapezius muscles and to determine whether long-term strength training and self-administration of androgenic-anabolic steroids are accompanied by changes in AR content. Biopsy samples were taken from eight high-level power-lifters (P), nine high-level power-lifters who used anabolic steroids (PAS) and six untrained subjects (U). Myonuclei and AR were visualised in cross-sections stained with the monoclonal antibody against AR and 4',6-diamidino-2-phenylindole. The proportion of AR-containing myonuclei per fibre cross-section was higher in the trapezius than in the vastus lateralis (P<0.05). In the trapezius, the proportion of AR-containing myonuclei was higher in P compared to U and in PAS compared to both P and U (P<0. 05). On the contrary, in the vastus lateralis, there were no differences in AR content between the three groups. Myonuclear number in both muscles was higher in P compared to U and in PAS compared to both P and U (P<0.05). In conclusion, AR content differs greatly between human neck and limb muscles. Moreover, the regulation of AR-containing myonuclei following training and self-administration of androgenic-anabolic steroids is muscle dependent.
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Bonnerud, PUmeå universitet,Anatomi
(author)
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Eriksson, AndersUmeå universitet,Anatomi(Swepub:ltu)anderi
(author)
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Thornell, Lars-EricUmeå universitet,Anatomi,Umeå University, Department of Integrative Medical Biology(Swepub:umu)lath0002
(author)
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Umeå universitetAnatomi
(creator_code:org_t)
Related titles
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In:Histochemistry and Cell Biology: Springer Science and Business Media LLC113:1, s. 25-290948-61431432-119X
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