Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:umu-83887" > Association Between...

1 of 1
Previous record
Next record
To hitlist

Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage

Carlsson, Axel C (author): Karolinska Institutet,Uppsala universitet,Geriatrik,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab

Ruge, Toralph (author): Uppsala universitet,Umeå universitet,Kirurgi,Geriatrik

Sundström, Johan (author): Uppsala universitet,Kardiovaskulär epidemiologi

Ingelsson, Erik (author): Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab

Larsson, Anders (author): Uppsala universitet,Biokemisk struktur och funktion

Lind, Lars (author): Uppsala universitet,Kardiovaskulär epidemiologi

Ärnlöv, Johan, 1970- (author): Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab

show less...

(creator_code:org_t)

Lippincott Williams & Wilkins, 2013
2013
English.
In: Hypertension. - : Lippincott Williams & Wilkins. - 0194-911X .- 1524-4563. ; 62:6, s. 1146-1151

Related links:: https://uu.diva-port... (primary) (Raw object); show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Our aim is to study associations between circulating endostatin, hypertension duration, and hypertensive target-organ damage. Long-term hypertension induces cardiovascular and renal remodeling. Circulating endostatin, a biologically active derivate of collagen XVIII, has been suggested to be a relevant marker for extracellular matrix turnover and remodeling in various diseases. However, the role of endostatin in hypertension and hypertensive target-organ damage is unclear. Serum endostatin was measured in 2 independent community-based cohorts: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 51%; n=812; mean age, 75 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=785; mean age, 77.6 years). Retrospective data on blood pressure measurements and antihypertensive medication (PIVUS >5 years, ULSAM >27 years), and cross-sectional data on echocardiographic left ventricular mass, endothelial function (endothelium-dependent vasodilation assessed by the invasive forearm model), and urinary albumin/creatinine ratio were available. In PIVUS, participants with 5 years of history of hypertension portrayed 0.42 SD (95% confidence interval, 0.23-0.61; P<0.001) higher serum endostatin, compared with that of normotensives. This association was replicated in ULSAM, in which participants with 27 years hypertension duration had the highest endostatin (0.57 SD higher; 95% confidence interval, 0.35-0.80; P<0.001). In addition, higher endostatin was associated with higher left ventricular mass, worsened endothelial function, and higher urinary albumin/creatinine ratio (P<0.03 for all) in participants with prevalent hypertension. Circulating endostatin is associated with the duration of hypertension, and vascular, myocardial, and renal indices of hypertensive target-organ damage. Further studies are warranted to assess the prognostic role of endostatin in individuals with hypertension.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

Keyword

angiogenesis effects
antiangiogenesis effects
cohort study
endothelial cells
epidemiology
extracellular matrix
Sweden
vascular stiffness
Hälsa och välfärd

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Hypertension (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Carlsson, Axel C; Ruge, Toralph; Sundström, Johan; Ingelsson, Erik; Larsson, Anders; Lind, Lars; show more...; Ärnlöv, Johan, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Hypertension

By the university: Umeå University; Högskolan Dalarna; Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se