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Epidemiology of Res...
Epidemiology of Respiratory Syncytial Virus-Associated Acute Lower Respiratory Tract Infection Hospitalizations Among HIV-Infected and HIV-Uninfected South African Children, 2010-2011
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Moyes, Jocelyn (author)
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Cohen, Cheryl (author)
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Pretorius, Marthi (author)
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Groome, Michelle (author)
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von Gottberg, Anne (author)
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Wolter, Nicole (author)
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Walaza, Sibongile (author)
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Haffejee, Sumayya (author)
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Chhagan, Meera (author)
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Naby, Fathima (author)
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Cohen, Adam L. (author)
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Tempia, Stefano (author)
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- Kahn, Kathleen (author)
- Umeå universitet,Epidemiologi och global hälsa,INDEPTH network, Accra, Ghana
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Dawood, Halima (author)
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Venter, Marietjie (author)
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Madhi, Shabir A. (author)
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(creator_code:org_t)
- 2013-11-21
- 2013
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 208:Supplement: 3, s. S217-S226
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background. There are limited data on respiratory syncytial virus (RSV) infection among children in settings with a high prevalence of human immunodeficiency virus (HIV). We studied the epidemiology of RSV-associated acute lower respiratory tract infection (ALRTI) hospitalizations among HIV-infected and HIV-uninfected children in South Africa. Methods. Children aged <5 years admitted to sentinel surveillance hospitals with physician-diagnosed neonatal sepsis or ALRTI were enrolled. Nasopharyngeal aspirates were tested by multiplex real-time polymerase chain reaction assays for RSV and other viruses. Associations between possible risk factors and severe outcomes for RSV infection among HIV-infected and uninfected children were examined. The relative risk of hospitalization in HIV-infected and HIV-uninfected children was calculated in 1 site with population denominators. Results. Of 4489 participants, 4293 (96%) were tested for RSV, of whom 1157 (27%) tested positive. With adjustment for age, HIV-infected children had a 3-5-fold increased risk of hospitalization with RSV-associated ALRTI (2010 relative risk, 5.6; [95% confidence interval (CI), 4.5-6.4]; 2011 relative risk, 3.1 [ 95% CI, 2.6-3.6]). On multivariable analysis, HIV-infected children with RSV-associated ALRTI had higher odds of death (adjusted odds ratio. 31.1; 95% CI, 5.4-179.8) and hospitalization for >5 days (adjusted odds ratio, 4.0; 95% CI, 1.5-10.6) than HIV-uninfected children. Conclusion. HIV-infected children have a higher risk of hospitalization with RSV-associated ALRTI and a poorer outcome than HIV-uninfected children. These children should be targeted for interventions aimed at preventing severe RSV disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- By the author/editor
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Moyes, Jocelyn
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Cohen, Cheryl
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Pretorius, Marth ...
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Groome, Michelle
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von Gottberg, An ...
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Wolter, Nicole
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show more...
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Walaza, Sibongil ...
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Haffejee, Sumayy ...
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Chhagan, Meera
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Naby, Fathima
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Cohen, Adam L.
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Tempia, Stefano
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Kahn, Kathleen
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Dawood, Halima
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Venter, Marietji ...
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Madhi, Shabir A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Journal of Infec ...
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Umeå University