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Inflammatory and me...
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Aleksandrova, Krasimira
(author)
Inflammatory and metabolic biomarkers and risk of liver and bilary tract cancer
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-07-29
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Wiley-Blackwell,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-85156
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85156URI
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https://doi.org/10.1002/hep.27016DOI
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https://lup.lub.lu.se/record/4713943URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:129690098URI
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https://gup.ub.gu.se/publication/204283URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however there is little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intra-hepatic bile duct (IBD) and gallbladder and bilary tract cancers outside of the liver (GBTC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). Over an average of 7.7 years, 296 participants developed HCC (n=125), GBTC (n=137) or IBD (n=34). Using risk set sampling, controls were selected in a 2:1 ratio and matched for recruitment center, age, sex, fasting status, time of blood collection. Baseline serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, total, high-molecular-weight (HMW) adiponectin, leptin, fetuin-a, and glutamatdehydrogenase (GLDH) were measured and incidence rate ratios (IRRs) and 95% confidence intervals (CI-s) estimated using conditional logistic regression. After adjustment for lifestyle factors, diabetes, hepatitis infection and adiposity measures, higher concentrations of CRP, IL-6, C-peptide and non-HMW adiponectin were associated with higher risk of HCC (IRR per doubling of concentrations = 1.22; 95%CI = 1.02-1.46, P=0.03; 1.90; 95%CI = 1.30-2.77, P=0.001; 2.25; 95%CI = 1.43-3.54, P=0.0005 and 2.09; 95%CI = 1.19-3.67, P=0.01, respectively). CRP was associated also with risk of GBTC (IRR = 1.22; 95%CI = 1.05-1.42, P=0.01). GLDH was associated with risks of HCC (IRR = 1.62; 95%CI = 1.25-2.11, P=0.0003) and IBD (IRR = 10.5; 95%CI = 2.20-50.90, P=0.003). The continuous net reclassification index was 0.63 for CRP, IL-6, C-peptide and non-HMW adiponectin, and 0.46 for GLDH indicating good predictive ability of these biomarkers. Conclusion: Elevated levels of biomarkers of inflammation and hyperinsulinemia are associated with a higher risk of HCC, independent of obesity and established liver cancer risk factors.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Boeing, Heiner
(author)
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Nöthlings, Ute
(author)
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Jenab, Mazda
(author)
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Fedirko, Veronika
(author)
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Kaaks, Rudolf
(author)
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Lukanova-McGregor, AnnekatrinUmeå universitet,Patologi,Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany(Swepub:umu)anlu0225
(author)
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Trichopoulou, Antonia
(author)
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Trichopoulos, Dimitrios
(author)
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Boffetta, Paolo
(author)
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Trepo, Elisabeth
(author)
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Westhpal, Sabine
(author)
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Duarte-Salles, Talita
(author)
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Stepien, Magdalena
(author)
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Overvad, Kim
(author)
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Tjønneland, Anne
(author)
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Halkjær, Jytte
(author)
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Boutron-Ruault, Marie-Christine
(author)
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Dossus, Laure
(author)
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Racine, Antoine
(author)
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Lagiou, Pagona
(author)
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Bamia, Christina
(author)
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Benetou, Vassiliki
(author)
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Agnoli, Claudia
(author)
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Palli, Domenico
(author)
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Panico, Salvatore
(author)
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Tumino, Rosario
(author)
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Vineis, Paolo
(author)
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Bueno-de-Mesquita, Bas
(author)
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Peeters, Petra H
(author)
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Gram, Inger Torhild
(author)
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Lund, Eiliv
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Quirós, J Ramón
(author)
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Agudo, Antonio
(author)
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Sánchez, María-José
(author)
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Gavrila, Diana
(author)
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Barricarte, Aurelio
(author)
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Dorronsoro, Miren
(author)
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Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)kir-boh
(author)
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Lindkvist, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlibjo
(author)
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Johansson, AndersUmeå universitet,Institutionen för odontologi,Näringsforskning(Swepub:umu)anjo0002
(author)
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Sund, Malin,1972-Umeå universitet,Kirurgi(Swepub:umu)masu0021
(author)
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Khaw, Kay-Tee
(author)
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Wareham, Nicholas
(author)
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Travis, Ruth C
(author)
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Riboli, Elio
(author)
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Pischon, Tobias
(author)
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Umeå universitetPatologi
(creator_code:org_t)
Related titles
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In:Hepatology: Wiley-Blackwell60:3, s. 858-8710270-91391527-3350
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Aleksandrova, Kr ...
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Boeing, Heiner
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Nöthlings, Ute
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Jenab, Mazda
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Fedirko, Veronik ...
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Kaaks, Rudolf
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Lukanova-McGrego ...
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Boffetta, Paolo
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Trepo, Elisabeth
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Westhpal, Sabine
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Duarte-Salles, T ...
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Stepien, Magdale ...
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Overvad, Kim
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Tjønneland, Anne
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Halkjær, Jytte
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Boutron-Ruault, ...
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Dossus, Laure
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Racine, Antoine
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Lagiou, Pagona
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Bamia, Christina
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Benetou, Vassili ...
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Agnoli, Claudia
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Palli, Domenico
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Panico, Salvator ...
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Tumino, Rosario
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Vineis, Paolo
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Bueno-de-Mesquit ...
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Peeters, Petra H
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Gram, Inger Torh ...
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Lund, Eiliv
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Weiderpass, Elis ...
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Quirós, J Ramón
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Agudo, Antonio
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Sánchez, María-J ...
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Gavrila, Diana
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Barricarte, Aure ...
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Dorronsoro, Mire ...
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Ohlsson, Bodil
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Lindkvist, Björn
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Johansson, Ander ...
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Sund, Malin, 197 ...
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Khaw, Kay-Tee
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Wareham, Nichola ...
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Travis, Ruth C
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Riboli, Elio
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Pischon, Tobias
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Hepatology
- By the university
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Umeå University
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Lund University
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Karolinska Institutet
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University of Gothenburg