Inflammatory and metabolic biomarkers and risk of liver and bilary tract cancer

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Aleksandrova, Krasimira (author)

Inflammatory and metabolic biomarkers and risk of liver and bilary tract cancer

Article/chapterEnglish2014

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2014-07-29
Wiley-Blackwell,2014
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:umu-85156
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85156URI
https://doi.org/10.1002/hep.27016DOI
https://lup.lub.lu.se/record/4713943URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:129690098URI
https://gup.ub.gu.se/publication/204283URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however there is little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intra-hepatic bile duct (IBD) and gallbladder and bilary tract cancers outside of the liver (GBTC) in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC). Over an average of 7.7 years, 296 participants developed HCC (n=125), GBTC (n=137) or IBD (n=34). Using risk set sampling, controls were selected in a 2:1 ratio and matched for recruitment center, age, sex, fasting status, time of blood collection. Baseline serum concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), C-peptide, total, high-molecular-weight (HMW) adiponectin, leptin, fetuin-a, and glutamatdehydrogenase (GLDH) were measured and incidence rate ratios (IRRs) and 95% confidence intervals (CI-s) estimated using conditional logistic regression. After adjustment for lifestyle factors, diabetes, hepatitis infection and adiposity measures, higher concentrations of CRP, IL-6, C-peptide and non-HMW adiponectin were associated with higher risk of HCC (IRR per doubling of concentrations = 1.22; 95%CI = 1.02-1.46, P=0.03; 1.90; 95%CI = 1.30-2.77, P=0.001; 2.25; 95%CI = 1.43-3.54, P=0.0005 and 2.09; 95%CI = 1.19-3.67, P=0.01, respectively). CRP was associated also with risk of GBTC (IRR = 1.22; 95%CI = 1.05-1.42, P=0.01). GLDH was associated with risks of HCC (IRR = 1.62; 95%CI = 1.25-2.11, P=0.0003) and IBD (IRR = 10.5; 95%CI = 2.20-50.90, P=0.003). The continuous net reclassification index was 0.63 for CRP, IL-6, C-peptide and non-HMW adiponectin, and 0.46 for GLDH indicating good predictive ability of these biomarkers. Conclusion: Elevated levels of biomarkers of inflammation and hyperinsulinemia are associated with a higher risk of HCC, independent of obesity and established liver cancer risk factors.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
liver cancer
biomarkers
hepatocellular carcinoma
bile duct cancer
inflammation
hyperinsulinemia
medicin
Medicine

Added entries (persons, corporate bodies, meetings, titles ...)

Boeing, Heiner (author)
Nöthlings, Ute (author)
Jenab, Mazda (author)
Fedirko, Veronika (author)
Kaaks, Rudolf (author)
Lukanova-McGregor, AnnekatrinUmeå universitet,Patologi,Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany(Swepub:umu)anlu0225 (author)
Trichopoulou, Antonia (author)
Trichopoulos, Dimitrios (author)
Boffetta, Paolo (author)
Trepo, Elisabeth (author)
Westhpal, Sabine (author)
Duarte-Salles, Talita (author)
Stepien, Magdalena (author)
Overvad, Kim (author)
Tjønneland, Anne (author)
Halkjær, Jytte (author)
Boutron-Ruault, Marie-Christine (author)
Dossus, Laure (author)
Racine, Antoine (author)
Lagiou, Pagona (author)
Bamia, Christina (author)
Benetou, Vassiliki (author)
Agnoli, Claudia (author)
Palli, Domenico (author)
Panico, Salvatore (author)
Tumino, Rosario (author)
Vineis, Paolo (author)
Bueno-de-Mesquita, Bas (author)
Peeters, Petra H (author)
Gram, Inger Torhild (author)
Lund, Eiliv (author)
Weiderpass, ElisabeteKarolinska Institutet (author)
Quirós, J Ramón (author)
Agudo, Antonio (author)
Sánchez, María-José (author)
Gavrila, Diana (author)
Barricarte, Aurelio (author)
Dorronsoro, Miren (author)
Ohlsson, BodilLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)kir-boh (author)
Lindkvist, BjörnGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xlibjo (author)
Johansson, AndersUmeå universitet,Institutionen för odontologi,Näringsforskning(Swepub:umu)anjo0002 (author)
Sund, Malin,1972-Umeå universitet,Kirurgi(Swepub:umu)masu0021 (author)
Khaw, Kay-Tee (author)
Wareham, Nicholas (author)
Travis, Ruth C (author)
Riboli, Elio (author)
Pischon, Tobias (author)
Umeå universitetPatologi (creator_code:org_t)

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In:Hepatology: Wiley-Blackwell60:3, s. 858-8710270-91391527-3350

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By the author/editor: Aleksandrova, Kr ...; Boeing, Heiner; Nöthlings, Ute; Jenab, Mazda; Fedirko, Veronik ...; Kaaks, Rudolf; show more...; Lukanova-McGrego ...; Trichopoulou, An ...; Trichopoulos, Di ...; Boffetta, Paolo; Trepo, Elisabeth; Westhpal, Sabine; Duarte-Salles, T ...; Stepien, Magdale ...; Overvad, Kim; Tjønneland, Anne; Halkjær, Jytte; Boutron-Ruault, ...; Dossus, Laure; Racine, Antoine; Lagiou, Pagona; Bamia, Christina; Benetou, Vassili ...; Agnoli, Claudia; Palli, Domenico; Panico, Salvator ...; Tumino, Rosario; Vineis, Paolo; Bueno-de-Mesquit ...; Peeters, Petra H; Gram, Inger Torh ...; Lund, Eiliv; Weiderpass, Elis ...; Quirós, J Ramón; Agudo, Antonio; Sánchez, María-J ...; Gavrila, Diana; Barricarte, Aure ...; Dorronsoro, Mire ...; Ohlsson, Bodil; Lindkvist, Björn; Johansson, Ander ...; Sund, Malin, 197 ...; Khaw, Kay-Tee; Wareham, Nichola ...; Travis, Ruth C; Riboli, Elio; Pischon, Tobias; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Hepatology

By the university: Umeå University; Lund University; Karolinska Institutet; University of Gothenburg

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