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Towards the introdu...
Towards the introduction of the 'Immunoscore' in the classification of malignant tumours
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Galon, Jerome (author)
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Mlecnik, Bernhard (author)
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Bindea, Gabriela (author)
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Angell, Helen K. (author)
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Berger, Anne (author)
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Lagorce, Christine (author)
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Lugli, Alessandro (author)
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Zlobec, Inti (author)
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Hartmann, Arndt (author)
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Bifulco, Carlo (author)
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Nagtegaal, Iris D. (author)
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- Palmqvist, Richard (author)
- Umeå universitet,Patologi
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- Masucci, Giuseppe V. (author)
- Karolinska Institutet
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Botti, Gerardo (author)
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Tatangelo, Fabiana (author)
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Delrio, Paolo (author)
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Maio, Michele (author)
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Laghi, Luigi (author)
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Grizzi, Fabio (author)
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Asslaber, Martin (author)
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D'Arrigo, Corrado (author)
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Vidal-Vanaclocha, Fernando (author)
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Zavadova, Eva (author)
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Chouchane, Lotfi (author)
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Ohashi, Pamela S. (author)
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Hafezi-Bakhtiari, Sara (author)
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Wouters, Bradly G. (author)
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Roehrl, Michael (author)
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Nguyen, Linh (author)
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Kawakami, Yutaka (author)
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Hazama, Shoichi (author)
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Okuno, Kiyotaka (author)
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Ogino, Shuji (author)
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Gibbs, Peter (author)
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Waring, Paul (author)
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Sato, Noriyuki (author)
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Torigoe, Toshihiko (author)
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Itoh, Kyogo (author)
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Patel, Prabhu S. (author)
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Shukla, Shilin N. (author)
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Wang, Yili (author)
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Kopetz, Scott (author)
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Sinicrope, Frank A. (author)
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Scripcariu, Viorel (author)
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Ascierto, Paolo A. (author)
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Marincola, Francesco M. (author)
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Fox, Bernard A. (author)
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Pages, Franck (author)
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(creator_code:org_t)
- 2013-12-10
- 2014
- English.
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In: Journal of Pathology. - : Wiley-Blackwell. - 0022-3417 .- 1096-9896. ; 232:2, s. 199-209
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Abstract
Subject headings
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- The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression-based stratification. These parameters rely on tumour-cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named Immunoscore' has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Immunoscore
- colorectal cancer
- colon carcinoma
- tumour microenvironment
- immune response
- classification
- prognostic markers
- predictive markers
- T cells
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Galon, Jerome
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Mlecnik, Bernhar ...
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Bindea, Gabriela
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Angell, Helen K.
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Berger, Anne
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Lagorce, Christi ...
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show more...
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Lugli, Alessandr ...
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Zlobec, Inti
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Hartmann, Arndt
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Bifulco, Carlo
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Nagtegaal, Iris ...
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Palmqvist, Richa ...
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Masucci, Giusepp ...
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Botti, Gerardo
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Tatangelo, Fabia ...
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Delrio, Paolo
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Maio, Michele
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Laghi, Luigi
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Grizzi, Fabio
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Asslaber, Martin
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D'Arrigo, Corrad ...
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Vidal-Vanaclocha ...
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Zavadova, Eva
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Chouchane, Lotfi
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Ohashi, Pamela S ...
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Hafezi-Bakhtiari ...
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Wouters, Bradly ...
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Roehrl, Michael
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Nguyen, Linh
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Kawakami, Yutaka
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Hazama, Shoichi
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Okuno, Kiyotaka
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Ogino, Shuji
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Gibbs, Peter
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Waring, Paul
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Sato, Noriyuki
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Torigoe, Toshihi ...
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Itoh, Kyogo
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Patel, Prabhu S.
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Shukla, Shilin N ...
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Wang, Yili
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Kopetz, Scott
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Sinicrope, Frank ...
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Scripcariu, Vior ...
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Ascierto, Paolo ...
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Marincola, Franc ...
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Fox, Bernard A.
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Pages, Franck
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Patho ...
- By the university
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Umeå University
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Karolinska Institutet