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Differences between...
Differences between men and women in the regulation of adipose 11 beta-HSD1 and in its association with adiposity and insulin resistance
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deSchoolmeester, J. (author)
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Palming, J. (author)
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Persson, T. (author)
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- Pereira, Maria J (author)
- Uppsala universitet,Endokrin diabetes och metabolism
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- Eriksson, Jan W (author)
- Uppsala universitet,Endokrin diabetes och metabolism
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Brown, H. (author)
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Gill, D. (author)
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- Renström, Frida (author)
- Umeå universitet,Enheten för biobanksforskning,Medicin
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- Lundgren, M. (author)
- Umeå universitet,Medicin
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Svensson, M. K. (author)
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Rees, A. (author)
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Eriksson, J. W. (author)
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(creator_code:org_t)
- 2013-06-20
- 2013
- English.
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In: Diabetes, obesity and metabolism. - : Wiley-Blackwell. - 1462-8902 .- 1463-1326. ; 15:11, s. 1056-1060
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- This study explored sex differences in 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) activity and gene expression in isolated adipocytes and adipose tissue (AT), obtained via subcutaneous biopsies from non-diabetic subjects [58 M, 64 F; age 48.3 +/- 15.3years, body mass index (BMI) 27.2 +/- 3.9kg/m(2)]. Relationships with adiposity and insulin resistance (IR) were addressed. Males exhibited higher 11-HSD1 activity in adipocytes than females, but there was no such difference for AT. In both men and women, adipocyte 11-HSD1 activity correlated positively with BMI, waist circumference, % body fat, adipocyte size and with serum glucose, triglycerides and low-density lipoprotein:high-density lipoprotein (LDL:HDL) ratio. Positive correlations with insulin, HOMA-IR and haemoglobin A1c (HbA1c) and a negative correlation with HDL-cholesterol were significant only in males. Conversely, 11-HSD1 activity in AT correlated with several markers of IR and adiposity in females but not in males, but the opposite pattern was found with respect to 11-HSD1 mRNA expression. This study suggests that there are sex differences in 11-HSD1 regulation and in its associations with markers of obesity and IR.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- 11β-hydroxysteroid dehydrogenase type 1
- 11 beta-hydroxysteroid dehydrogenase type 1
- adipose tissue
- adipocytes
- obesity
- sex
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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deSchoolmeester, ...
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Palming, J.
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Persson, T.
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Pereira, Maria J
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Eriksson, Jan W
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Brown, H.
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show more...
-
Gill, D.
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Renström, Frida
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Lundgren, M.
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Svensson, M. K.
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Rees, A.
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Eriksson, J. W.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetes, obesit ...
- By the university
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Umeå University
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Uppsala University