Search: onr:"swepub:oai:DiVA.org:umu-85710" >
Transient cytokine ...
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
-
Baeyens, Luc (author)
-
Lemper, Marie (author)
-
Leuckx, Gunter (author)
-
show more...
-
De Groef, Sofie (author)
-
Bonfanti, Paola (author)
-
Stange, Geert (author)
-
Shemer, Ruth (author)
-
- Nord, Christoffer (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
Scheel, David W (author)
-
Pan, Fong C (author)
-
- Ahlgren, Ulf (author)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
-
Gu, Guoqiang (author)
-
Stoffers, Doris A (author)
-
Dor, Yuval (author)
-
Ferrer, Jorge (author)
-
Gradwohl, Gerard (author)
-
Wright, Christopher VE (author)
-
Van de Casteele, Mark (author)
-
German, Michael S (author)
-
Bouwens, Luc (author)
-
Heimberg, Harry (author)
-
show less...
-
(creator_code:org_t)
- 2013-11-17
- 2014
- English.
-
In: Nature Biotechnology. - : Springer Science and Business Media LLC. - 1087-0156 .- 1546-1696. ; 32:1, s. 76-83
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic hyperglycemia efficiently stimulates the conversion of terminally differentiated acinar cells to beta-like cells. Newly generated beta-like cells are epigenetically reprogrammed, functional and glucose responsive, and they reinstate normal glycemic control for up to 248 d. The regenerative process depends on Stat3 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells. In contrast to previous work demonstrating in vivo conversion of acinar cells to beta-like cells by viral delivery of exogenous transcription factors, our approach achieves acinar-to-beta-cell reprogramming through transient cytokine exposure rather than genetic modification.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Baeyens, Luc
-
Lemper, Marie
-
Leuckx, Gunter
-
De Groef, Sofie
-
Bonfanti, Paola
-
Stange, Geert
-
show more...
-
Shemer, Ruth
-
Nord, Christoffe ...
-
Scheel, David W
-
Pan, Fong C
-
Ahlgren, Ulf
-
Gu, Guoqiang
-
Stoffers, Doris ...
-
Dor, Yuval
-
Ferrer, Jorge
-
Gradwohl, Gerard
-
Wright, Christop ...
-
Van de Casteele, ...
-
German, Michael ...
-
Bouwens, Luc
-
Heimberg, Harry
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Nature Biotechno ...
- By the university
-
Umeå University