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HIV and Influenza V...
HIV and Influenza Virus Infections Are Associated With Increased Blood Pneumococcal Load : A Prospective, Hospital-Based Observational Study in South Africa, 2009-2011
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Wolter, Nicole (author)
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Cohen, Cheryl (author)
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Tempia, Stefano (author)
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Madhi, Shabir A. (author)
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Venter, Marietjie (author)
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Moyes, Jocelyn (author)
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Walaza, Sibongile (author)
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Kgokong, Babatyi Malope (author)
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Groome, Michelle (author)
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du Plessis, Mignon (author)
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Pretorius, Marthi (author)
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Dawood, Halima (author)
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- Kahn, Kathleen (author)
- Umeå universitet,Epidemiologi och global hälsa,Center for Global Health Research
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Variava, Ebrahim (author)
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Klugman, Keith P. (author)
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von Gottberg, Anne (author)
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(creator_code:org_t)
- 2013-08-06
- 2014
- English.
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In: Journal of Infectious Diseases. - : Oxford University Press. - 0022-1899 .- 1537-6613. ; 209:1, s. 56-65
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background. Increased pneumococcal loads are associated with severe outcomes. We determined the prevalence of pneumococcal DNA in blood specimens from patients hospitalized with acute lower respiratory tract infection and identified factors associated with invasive pneumococcal pneumonia, bacterial loads, and death. Methods. A total of 8523 patients were enrolled as part of prospective hospital-based surveillance. Blood was collected for quantitative pneumococcal (tytA) detection, and nasopharyngeal specimens were collected for detection of influenza virus and other respiratory viruses by real-time polymerase chain reaction. Results. Of 6396 cases (75%) with /ytA results, 422 (7%) were positive for pneumococcal DNA. The prevalences of human immunodeficiency virus (HIV) and influenza virus were 51% (2965/5855) and 8% (485/6358), respectively. On multivariable analysis, HIV infection (adjusted odds ratio [aOR], 2.4; 95% confidence interval [CI], 1.6-3.6), influenza virus coinfection (aOR, 1.4; 95% CI, 1.2-2.1), oxygen therapy during admission (a0R, 1.6; 95% CI, 1.1-2.3) and in-hospital death (aOR, 2.1; 95% CI, 1.1-4.0) were significantly associated with increased pneumococcal load. Among /ytA-positive patients, after adjustment for length of hospitalization, duration of symptoms, and oxygen therapy during admission, pneumococcal loads >= 10,000 DNA copies/mi. (a0R, 3.6; 95% CI, 1.8-7.2) were associated with increased risk of death. Conclusions. HIV and influenza virus infections were associated with elevated pneumococcal loads, which, in turn, were associated with increased risk of death.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Streptococcus pneurnoniae
- pneumococcal pneumonia
- bacterial load
- HIV
- influenza
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wolter, Nicole
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Cohen, Cheryl
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Tempia, Stefano
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Madhi, Shabir A.
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Venter, Marietji ...
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Moyes, Jocelyn
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show more...
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Walaza, Sibongil ...
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Kgokong, Babatyi ...
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Groome, Michelle
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du Plessis, Mign ...
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Pretorius, Marth ...
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Dawood, Halima
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Kahn, Kathleen
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Variava, Ebrahim
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Klugman, Keith P ...
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von Gottberg, An ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Journal of Infec ...
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Umeå University