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Self-rated health a...
Self-rated health and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition-InterAct study : a case-cohort study
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- Wennberg, Patrik (author)
- Umeå universitet,Allmänmedicin
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- Rolandsson, Olov (author)
- Umeå universitet,Allmänmedicin
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van der A, Daphne L. (author)
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Spijkerman, Annemieke M. W. (author)
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Kaaks, Rudolf (author)
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Boeing, Heiner (author)
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Feller, Silke (author)
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Bergmann, Manuela M. (author)
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Langenberg, Claudia (author)
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Sharp, Stephen J. (author)
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Forouhi, Nita (author)
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Riboli, Elio (author)
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Wareham, Nicholas (author)
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(creator_code:org_t)
- 2013-03-06
- 2013
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 3:3, s. e002436-
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Abstract
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- Objectives:To investigate the association between self-rated health and risk of type 2 diabetes and whether the strength of this association is consistent across five European centres.Design: Population-based prospective case-cohort study.Setting: Enrolment took place between 1992 and 2000 in five European centres (Bilthoven, Cambridge, Heidelberg, Potsdam and Umea).Participants: Self-rated health was assessed by a baseline questionnaire in 3399 incident type 2 diabetic case participants and a centre-stratified subcohort of 4619 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study which was drawn from a total cohort of 340 234 participants in the EPIC.Primary outcome measure: Prentice-weighted Cox regression was used to estimate centre-specific HRs and 95% CIs for incident type 2 diabetes controlling for age, sex, centre, education, body mass index (BMI), smoking, alcohol consumption, energy intake, physical activity and hypertension. The centre-specific HRs were pooled across centres by random effects meta-analysis.Results: Low self-rated health was associated with a higher hazard of type 2 diabetes after adjusting for age and sex (pooled HR 1.67, 95% CI 1.48 to 1.88). After additional adjustment for health-related variables including BMI, the association was attenuated but remained statistically significant (pooled HR 1.29, 95% CI 1.09 to 1.53). I-2 index for heterogeneity across centres was 13.3% (p=0.33).Conclusions: Low self-rated health was associated with a higher risk of type 2 diabetes. The association could be only partly explained by other health-related variables, of which obesity was the strongest. We found no indication of heterogeneity in the association between self-rated health and type 2 diabetes mellitus across the European centres.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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BMJ Open
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- By the author/editor
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Wennberg, Patrik
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Rolandsson, Olov
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van der A, Daphn ...
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Spijkerman, Anne ...
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Kaaks, Rudolf
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Boeing, Heiner
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show more...
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Feller, Silke
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Bergmann, Manuel ...
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Langenberg, Clau ...
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Sharp, Stephen J ...
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Forouhi, Nita
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Riboli, Elio
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Wareham, Nichola ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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BMJ Open
- By the university
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Umeå University