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  • Wennberg, PatrikUmeå universitet,Allmänmedicin (author)

Self-rated health and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition-InterAct study : a case-cohort study

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-03-06
  • BMJ,2013
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-86864
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-86864URI
  • https://doi.org/10.1136/bmjopen-2012-002436DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objectives:To investigate the association between self-rated health and risk of type 2 diabetes and whether the strength of this association is consistent across five European centres.Design: Population-based prospective case-cohort study.Setting: Enrolment took place between 1992 and 2000 in five European centres (Bilthoven, Cambridge, Heidelberg, Potsdam and Umea).Participants: Self-rated health was assessed by a baseline questionnaire in 3399 incident type 2 diabetic case participants and a centre-stratified subcohort of 4619 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study which was drawn from a total cohort of 340 234 participants in the EPIC.Primary outcome measure: Prentice-weighted Cox regression was used to estimate centre-specific HRs and 95% CIs for incident type 2 diabetes controlling for age, sex, centre, education, body mass index (BMI), smoking, alcohol consumption, energy intake, physical activity and hypertension. The centre-specific HRs were pooled across centres by random effects meta-analysis.Results: Low self-rated health was associated with a higher hazard of type 2 diabetes after adjusting for age and sex (pooled HR 1.67, 95% CI 1.48 to 1.88). After additional adjustment for health-related variables including BMI, the association was attenuated but remained statistically significant (pooled HR 1.29, 95% CI 1.09 to 1.53). I-2 index for heterogeneity across centres was 13.3% (p=0.33).Conclusions: Low self-rated health was associated with a higher risk of type 2 diabetes. The association could be only partly explained by other health-related variables, of which obesity was the strongest. We found no indication of heterogeneity in the association between self-rated health and type 2 diabetes mellitus across the European centres.

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  • Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
  • van der A, Daphne L. (author)
  • Spijkerman, Annemieke M. W. (author)
  • Kaaks, Rudolf (author)
  • Boeing, Heiner (author)
  • Feller, Silke (author)
  • Bergmann, Manuela M. (author)
  • Langenberg, Claudia (author)
  • Sharp, Stephen J. (author)
  • Forouhi, Nita (author)
  • Riboli, Elio (author)
  • Wareham, Nicholas (author)
  • Umeå universitetAllmänmedicin (creator_code:org_t)

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  • In:BMJ Open: BMJ3:3, s. e002436-2044-6055

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