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Self-rated health a...
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Wennberg, PatrikUmeå universitet,Allmänmedicin
(author)
Self-rated health and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition-InterAct study : a case-cohort study
- Article/chapterEnglish2013
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2013-03-06
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BMJ,2013
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-86864
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-86864URI
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https://doi.org/10.1136/bmjopen-2012-002436DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Objectives:To investigate the association between self-rated health and risk of type 2 diabetes and whether the strength of this association is consistent across five European centres.Design: Population-based prospective case-cohort study.Setting: Enrolment took place between 1992 and 2000 in five European centres (Bilthoven, Cambridge, Heidelberg, Potsdam and Umea).Participants: Self-rated health was assessed by a baseline questionnaire in 3399 incident type 2 diabetic case participants and a centre-stratified subcohort of 4619 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study which was drawn from a total cohort of 340 234 participants in the EPIC.Primary outcome measure: Prentice-weighted Cox regression was used to estimate centre-specific HRs and 95% CIs for incident type 2 diabetes controlling for age, sex, centre, education, body mass index (BMI), smoking, alcohol consumption, energy intake, physical activity and hypertension. The centre-specific HRs were pooled across centres by random effects meta-analysis.Results: Low self-rated health was associated with a higher hazard of type 2 diabetes after adjusting for age and sex (pooled HR 1.67, 95% CI 1.48 to 1.88). After additional adjustment for health-related variables including BMI, the association was attenuated but remained statistically significant (pooled HR 1.29, 95% CI 1.09 to 1.53). I-2 index for heterogeneity across centres was 13.3% (p=0.33).Conclusions: Low self-rated health was associated with a higher risk of type 2 diabetes. The association could be only partly explained by other health-related variables, of which obesity was the strongest. We found no indication of heterogeneity in the association between self-rated health and type 2 diabetes mellitus across the European centres.
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Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005
(author)
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van der A, Daphne L.
(author)
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Spijkerman, Annemieke M. W.
(author)
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Kaaks, Rudolf
(author)
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Boeing, Heiner
(author)
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Feller, Silke
(author)
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Bergmann, Manuela M.
(author)
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Langenberg, Claudia
(author)
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Sharp, Stephen J.
(author)
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Forouhi, Nita
(author)
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Riboli, Elio
(author)
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Wareham, Nicholas
(author)
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Umeå universitetAllmänmedicin
(creator_code:org_t)
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In:BMJ Open: BMJ3:3, s. e002436-2044-6055
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Feller, Silke
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