Search: onr:"swepub:oai:DiVA.org:umu-87398" > Gender and telomere...
Fältnamn | Indikatorer | Metadata |
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000 | 05750naa a2201045 4500 | |
001 | oai:DiVA.org:umu-87398 | |
003 | SwePub | |
008 | 140331s2014 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:ca7f11a7-3f72-413a-8a55-2a5f13d87137 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-873982 URI |
024 | 7 | a https://doi.org/10.1016/j.exger.2013.12.0042 DOI |
024 | 7 | a https://lup.lub.lu.se/record/42230412 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a for2 swepub-publicationtype |
100 | 1 | a Gardner, Michael4 aut |
245 | 1 0 | a Gender and telomere length :b Systematic review and meta-analysis |
264 | 1 | b Elsevier,c 2014 |
338 | a print2 rdacarrier | |
520 | a Background: It is widely believed that females have longer telomeres than males, although results from studies have been contradictory. Methods: We carried out a systematic review and meta-analyses to test the hypothesis that in humans, females have longer telomeres than males and that this association becomes stronger with increasing age. Searches were conducted in EMBASE and MEDLINE (by November 2009) and additional datasets were obtained from study investigators. Eligible observational studies measured telomeres for both females and males of any age, had a minimum sample size of 100 and included participants not part of a diseased group. We calculated summary estimates using random-effects meta-analyses. Heterogeneity between studies was investigated using sub-group analysis and meta-regression. Results: Meta-analyses from 36 cohorts (36,230 participants) showed that on average females had longer telomeres than males (standardised difference in telomere length between females and males 0.090, 95% CI 0.015, 0.166; age-adjusted). There was little evidence that these associations varied by age group (p = 1.00) or cell type (p = 0.29). However, the size of this difference did vary by measurement methods, with only Southern blot but neither real-time PCR nor Flow-FISH showing a significant difference. This difference was not associated with random measurement error. Conclusions: Telomere length is longer in females thanmales, although this difference was not universally found in studies that did not use Southern blot methods. Further research on explanations for the methodological differences is required. (C) 2013 Published by Elsevier Inc. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng |
653 | a Gender | |
653 | a Telomere length | |
653 | a Systematic review and meta-analysis | |
653 | a Measurement methods | |
653 | a Epidemiology | |
700 | 1 | a Bann, David4 aut |
700 | 1 | a Wiley, Laura4 aut |
700 | 1 | a Cooper, Rachel4 aut |
700 | 1 | a Hardy, Rebecca4 aut |
700 | 1 | a Nitsch, Dorothea4 aut |
700 | 1 | a Martin-Ruiz, Carmen4 aut |
700 | 1 | a Shiels, Paul4 aut |
700 | 1 | a Sayer, Avan Aihie4 aut |
700 | 1 | a Barbieri, Michelangela4 aut |
700 | 1 | a Bekaert, Sofie4 aut |
700 | 1 | a Bischoff, Claus4 aut |
700 | 1 | a Brooks-Wilson, Angela4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Christensen, Kaare4 aut |
700 | 1 | a De Meyer, Tim4 aut |
700 | 1 | a Deary, Ian4 aut |
700 | 1 | a Der, Geoff4 aut |
700 | 1 | a Roux, Ana Diez4 aut |
700 | 1 | a Fitzpatrick, Annette4 aut |
700 | 1 | a Hajat, Anjum4 aut |
700 | 1 | a Halaschek-Wiener, Julius4 aut |
700 | 1 | a Harris, Sarah4 aut |
700 | 1 | a Hunt, Steven C.4 aut |
700 | 1 | a Jagger, Carol4 aut |
700 | 1 | a Jeon, Hyo-Sung4 aut |
700 | 1 | a Kaplan, Robert4 aut |
700 | 1 | a Kimura, Masayuki4 aut |
700 | 1 | a Lansdorp, Peter4 aut |
700 | 1 | a Li, Changyong4 aut |
700 | 1 | a Maeda, Toyoki4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Nawrot, Tim S.4 aut |
700 | 1 | a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni |
700 | 1 | a Nordfjäll, Katarinau Umeå universitet,Institutionen för medicinsk biovetenskap4 aut0 (Swepub:umu)kaanll02 |
700 | 1 | a Paolisso, Giuseppe4 aut |
700 | 1 | a Ren, Fu4 aut |
700 | 1 | a Riabowol, Karl4 aut |
700 | 1 | a Robertson, Tony4 aut |
700 | 1 | a Roos, Goran4 aut |
700 | 1 | a Staessen, Jan A.4 aut |
700 | 1 | a Spector, Tim4 aut |
700 | 1 | a Tang, Nelson4 aut |
700 | 1 | a Unryn, Brad4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Woo, Jean4 aut |
700 | 1 | a Xing, Chao4 aut |
700 | 1 | a Yadegarfar, Mohammad E.4 aut |
700 | 1 | a Park, Jae Yong4 aut |
700 | 1 | a Young, Neal4 aut |
700 | 1 | a Kuh, Diana4 aut |
700 | 1 | a von Zglinicki, Thomas4 aut |
700 | 1 | a Ben-Shlomo, Yoav4 aut |
710 | 2 | a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Experimental Gerontologyd : Elsevierg 51, s. 15-27q 51<15-27x 0531-5565x 1873-6815 |
856 | 4 | u https://lirias.kuleuven.be/bitstream/123456789/449926/1/14-08-P.pdf |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24365661?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.exger.2013.12.004y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87398 |
856 | 4 8 | u https://doi.org/10.1016/j.exger.2013.12.004 |
856 | 4 8 | u https://lup.lub.lu.se/record/4223041 |
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