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Type 1 diabetes and...
Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6
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- Penha-Gonçalves, Carlos (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department for Cell and Molecular Biology, University of Umezå, Umeå, Sweden
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- Leijon, Kristina, 1967- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Cell and Molecular Biology. University of Umeå
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- Persson, Linda (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department for Cell and Molecular Biology, University of Umezå, Umeå, Sweden
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- Holmberg, Dan, 1954- (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Cell and Molecular Biology. University of Umeå
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(creator_code:org_t)
- Elsevier, 1995
- 1995
- English.
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In: Genomics. - : Elsevier. - 0888-7543 .- 1089-8646. ; 28:3, s. 398-404
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Quantitative trait loci mapping was used to identify the chromosomal location of genes that contribute to increase the resistance to apoptosis induced in immature CD4+8+ thymocytes. An F2 intercross of the nonobese diabetic (NOD) mouse (displaying an apoptosis-resistance phenotype) and the C57BL/6 mouse (displaying a nonresistance phenotype) was phenotypically analyzed and genotyped for 32 murine microsatellite polymorphisms. Maximum likelihood methods identified a region on the distal part of chromosome 6 that is linked to dexamethazone-induced apoptosis (lod score = 3.46) and accounts for 14% of the phenotypic variation. This chromosomal region contains the diabetes susceptibility locus Idd6, suggesting that the apoptosis-resistance phenotype constitutes a pathogenesis factor in IDDM of NOD mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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