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Diabetes induction in C57BL/6 mice reconstituted with lymphocytes of nonobese diabetic C57BL/6 mouse embryo aggregation chimeras

Colucci, Francesco (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),INSERM U429, Necker Hospital, Paris, France,Department for Cell and Molecular Biology, University of Umeå, Umeå, Sweden
Bergman, Marie-Louise (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department for Cell and Molecular Biology, University of Umeå, Umeå, Sweden
Lejon, Kristina, 1967- (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Cell and Molecular Biology. University of Umeå
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Holmberg, Dan, 1954- (author)
Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Cell and Molecular Biology. University of Umeå
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 (creator_code:org_t)
Wiley-Blackwell, 1998
1998
English.
In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 48:6, s. 571-576
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • To determine whether the genetic background of the insulin-producing beta cells of the pancreas contributes to autoimmune diabetes susceptibility, we have used a model of the disease based on transferring spleen cells from nonobese diabetic (NOD) <--> C57BL/6 (B6) embryo aggregation (EA) chimeras into B6 and NOD irradiated mice. Insulitis and diabetes could be induced into both B6 and NOD hosts, albeit with low incidence. Cyclophosphamide (CY) treatment, known to accelerate diabetes in prediabetic NOD mice, was found to increase diabetes incidence up to 50-60% in both B6 and NOD mice reconstituted with chimeric splenocytes, while diabetes did not occur in CY-treated B6 mice reconstituted with B6 splenocytes. We conclude that the genetic make-up of the target organ does not affect the final stage of the pathogenesis of insulin-dependent diabetes mellitus.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)

Keyword

immunologi
Immunology

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ref (subject category)
art (subject category)

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Colucci, Frances ...
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Holmberg, Dan, 1 ...
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MEDICAL AND HEALTH SCIENCES
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Scandinavian Jou ...
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Umeå University

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