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The CD8alpha+ dendr...
The CD8alpha+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
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- Belz, Gabrielle T (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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- Behrens, Georg M N (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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- Smith, Chris M (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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- Miller, Jacques F A P (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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- Jones, Claerwen (author)
- Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
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- Lejon, Kristina, 1967- (author)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Fathman, C. Garrison (author)
- Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
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- Mueller, Scott N (author)
- Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
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- Shortman, Ken (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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- Carbone, Francis R (author)
- Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
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- Heath, William R (author)
- Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia
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(creator_code:org_t)
- 2002-10-14
- 2002
- English.
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In: Journal of Experimental Medicine. - : The Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 196:8, s. 1099-1104
- Related links:
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http://jem.rupress.o...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow-derived cell type that stimulates the proliferation and ultimate deletion of self-reactive CD8 T cells. This process has been referred to as cross-tolerance. Here, we characterize the elusive cell type responsible for inducing cross-tolerance as a CD8alpha(+) dendritic cell (DC). To achieve this aim, transgenic mice were generated expressing yellow fluorescent protein (YFP) linked to CTL epitopes for ovalbumin and glycoprotein B (gB) of herpes simplex virus under the rat insulin promoter (RIP). Although tracking of YFP was inconclusive, the use of a highly sensitive gB-specific hybridoma that produced beta-galactosidase on encounter with antigen, enabled detection of antigen presentation by cells isolated from the pancreatic lymph node. This showed that a CD11c(+)CD8alpha(+) cell was responsible for cross-tolerance, the same DC subset as previously implicated in cross-priming. These data indicate that CD8alpha(+) DCs play a critical role in both tolerance and immunity to cell-associated antigens, providing a potential mechanism by which cytotoxic T lymphocyte can be immunized to viral antigens while maintaining tolerance to self.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- immunologi
- Immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Belz, Gabrielle ...
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Behrens, Georg M ...
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Smith, Chris M
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Miller, Jacques ...
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Jones, Claerwen
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Lejon, Kristina, ...
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show more...
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Fathman, C. Garr ...
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Mueller, Scott N
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Shortman, Ken
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Carbone, Francis ...
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Heath, William R
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Umeå University