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Single nucleotide p...
Single nucleotide polymorphism analysis of corticotropin-releasing factor-binding protein gene in bipolar disorder
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- Van Den Eede, Filip (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology ; Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Antwerp ; Department of Psychiatry, University Hospital Antwerp, Edegem
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- Venken, Tine (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology
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- Van Den Bogaert, Ann (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology
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- Del-Favero, Jurgen (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology
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- Norrback, Karl-Fredrik (author)
- Umeå universitet,Psykiatri
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- Nilsson, Lars Göran (author)
- Department of Psychology, Stockholm University, Stockholm, Sweden
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri,Department of Psychology, Stockholm University, Stockholm, Sweden
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- Van Broeckhoven, Christine (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology
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- Claes, Stephan J. (author)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology ; Department of Psychiatry, University Hospital Gasthuisberg, Leuven, Belgium
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2007
- 2007
- English.
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In: Psychiatric Genetics. - : Lippincott Williams & Wilkins. - 0955-8829 .- 1473-5873. ; 17:5, s. 304-307
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- bipolar disorder
- corticotropin-releasing factor-binding protein
- genetics
- hypothalamic-pituitary-adrenal axis
- vulnerability
Publication and Content Type
- ref (subject category)
- art (subject category)
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