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Dietary intake of a...
Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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Lujan-Barroso, Leila (author)
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González, Carlos Alberto (author)
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Slimani, Nadia (author)
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Obón-Santacana, Mireia (author)
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Ferrari, Pietro (author)
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Freisling, Heinz (author)
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Overvad, Kim (author)
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Clavel-Chapelon, Françoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Racine, Antoine (author)
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Katzke, Verena (author)
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Kühn, Tilman (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Quirós, J Ramón (author)
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Sánchez-Cantalejo, Emilio (author)
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Amiano, Pilar (author)
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Navarro, Carmen (author)
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Barricarte, Aurelio (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Travis, Ruth C (author)
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Trichopoulou, Antonia (author)
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Bamia, Christina (author)
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Benetou, Vassiliki (author)
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Saieva, Calogero (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Vineis, Paolo (author)
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Mattiello, Amalia (author)
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Bueno-de-Mesquita, H Bas (author)
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Siersema, Peter D (author)
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Numans, Mattijs E (author)
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Peeters, Petra H (author)
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Ericson, Ulrika (author)
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Wirfält, Elisabet (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
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- Johansson, Mattias (author)
- Umeå universitet,Enheten för biobanksforskning
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Skeie, Guri (author)
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Riboli, Elio (author)
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Boeing, Heiner (author)
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Duell, Eric J (author)
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(creator_code:org_t)
- 2014-02-16
- 2014
- English.
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In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 25:5, s. 639-646
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- PURPOSE: The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.METHODS: Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day.RESULTS: After a mean follow-up of 11 years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HRQ2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61), but not in the fourth quartile, and there was no evidence for a linear dose-response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake.CONCLUSIONS: In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Esophageal cancer
- Esophageal squamous cell carcinoma
- Esophageal adenocarcinoma
- Acrylamide intake
- Cohort
- Nutrition
Publication and Content Type
- ref (subject category)
- art (subject category)
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Lujan-Barroso, L ...
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González, Carlos ...
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Slimani, Nadia
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Obón-Santacana, ...
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Ferrari, Pietro
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Freisling, Heinz
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show more...
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Overvad, Kim
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Racine, Antoine
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Katzke, Verena
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Kühn, Tilman
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Tjønneland, Anne
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Olsen, Anja
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Quirós, J Ramón
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Sánchez-Cantalej ...
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Amiano, Pilar
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Navarro, Carmen
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Barricarte, Aure ...
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Khaw, Kay-Tee
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Wareham, Nick
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Travis, Ruth C
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Trichopoulou, An ...
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Bamia, Christina
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Benetou, Vassili ...
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Saieva, Calogero
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Grioni, Sara
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Tumino, Rosario
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Vineis, Paolo
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Mattiello, Amali ...
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Bueno-de-Mesquit ...
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Siersema, Peter ...
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Numans, Mattijs ...
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Peeters, Petra H
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Ericson, Ulrika
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Wirfält, Elisabe ...
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Sund, Malin, 197 ...
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Johansson, Matti ...
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Weiderpass, Elis ...
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Skeie, Guri
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Riboli, Elio
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Boeing, Heiner
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Duell, Eric J
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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Cancer Causes an ...
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Umeå University
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Karolinska Institutet