SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:umu-88545"
 

Search: onr:"swepub:oai:DiVA.org:umu-88545" > Indications that br...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Rudberg, S (author)

Indications that branched chain amino acids, in addition to glucagon, affect the glomerular filtration rate after a high protein diet in insulin-dependent diabetes

  • Article/chapterEnglish1991

Publisher, publication year, extent ...

  • Edinburgh, Scotland :Teviot-Kimpton Publications,1991
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-88545
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88545URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Hormonal changes and whole blood free amino acid levels and their relation to renal function were measured in 12 insulin-dependent diabetic patients after two 10-day periods with a diet consisting of 10% and 20% respectively of the energy as protein. The patients were 15-21 years old and mean duration of diabetes was 12 (5-20) years. Glomerular filtration rate, renal plasma flow, and albumin excretion rate were measured together with plasma concentrations of glucagon, growth hormone, insulin-like growth factor 1 (IGF-1), somatostatin, serum insulin and free amino acids in blood. Glomerular filtration rate was 123 +/- 3 ml/min/1.73 m2 on high protein diet and 113 +/- 3 ml/min/1.73 m2 on low protein diet (p = 0.02). Renal plasma flow was unchanged. Glucagon, IGF-1, branch chained amino acids (BCAA), tyrosine, phenylalanine, lysine, and methionine were increased after the high protein diet. Growth hormone, somatostatin, insulin, and other amino acids remained unchanged. The increase in glomerular filtration rate was significantly correlated to the increase in glucagon, isoleucine, and valine (glucagon r = 0.71, p = 0.01, isoleucine r = 0.59, p = 0.04, valine r = 0.62, p = 0.03). In a multiple regression model the increase in glomerular filtration correlated most strongly to the increase in isoleucine, followed by valine and glucagon. Together these variables explained 88% of the total variance of the change in glomerular filtration rate (r2 = 0.88, p = 0.001). Albumin excretion rate was correlated to IGF-1 (r = 0.86, p < 0.001) on the high protein diet. The regulation of GFR seems to depend on a combined effect of BCCA and glucagon, whereas microalbuminuria seems to be related to IGF-1.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dahlquist, GiselaSachs' Children's Hospitals, Department of Pediatrics(Swepub:umu)gida0001 (author)
  • Aperia, A (author)
  • Lindblad, B S (author)
  • Efendic, S (author)
  • Skottner, A (author)
  • Persson, B (author)
  • Sachs' Children's Hospitals, Department of Pediatrics (creator_code:org_t)

Related titles

  • In:Diabetes researchEdinburgh, Scotland : Teviot-Kimpton Publications16:3, s. 101-1090265-5985

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Find more in SwePub

By the author/editor
Rudberg, S
Dahlquist, Gisel ...
Aperia, A
Lindblad, B S
Efendic, S
Skottner, A
show more...
Persson, B
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
Diabetes researc ...
By the university
Umeå University

Search outside SwePub

Wikipedia about the author:
S_Rudberg
Rudberg, S
en

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view