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Possible release of...
Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal streptococcus and actinomyces species.
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Li, T (author)
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Bratt, P (author)
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Jonsson, AP (author)
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Ryberg, M (author)
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- Johansson, Ingegerd (author)
- Umeå universitet,Kariologi
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Griffiths, WJ (author)
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- Bergman, T (author)
- Karolinska Institutet
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- Strömberg, Nicklas (author)
- Umeå universitet,Kariologi
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: Infection and Immunity. - 0019-9567 .- 1098-5522. ; 68:9, s. 5425-9
- Related links:
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr(1)-Pro(104)Pro(105) and a Gly(111)-Pro(149)Gln(150) peptide together with a presumed Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) pentapeptide. The synthetic Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.
Publication and Content Type
- ref (subject category)
- art (subject category)
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