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Change in paternal ...
Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren
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- Bygren, Lars Olov, 1936- (author)
- Karolinska Institutet,Umeå universitet,Institutionen för samhällsmedicin och rehabilitering,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden,Department of Bioscience and Nutrition, Karolinska Institute, Stockholm, Sweden,Department of Biosciences and Nutrition, Karolinska Institutet; Department of Community Medicine and Rehabilitation, University of Umeå
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- Tinghög, Petter (author)
- Karolinska Institutet,Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden
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- Carstensen, John (author)
- Linköpings universitet,Avdelningen för hälsa och samhälle,Filosofiska fakulteten
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- Edvinsson, Sören, 1953- (author)
- Umeå universitet,Demografiska databasen,Arcum,The Demographic Database, University of Umeå, Sweden
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- Kaati, Gunnar (author)
- Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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- Pembrey, Marcus E. (author)
- Institute of Child Health, University College London, London, UK
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- Sjöström, Michael (author)
- Karolinska Institutet,Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
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(creator_code:org_t)
- BioMed Central, 2014
- 2014
- English.
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In: BMC Genetics. - : BioMed Central. - 1471-2156. ; 15, s. 12-
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Abstract
Subject headings
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- Background: This study investigated whether large fluctuations in food availability during grandparents' early development influenced grandchildren's cardiovascular mortality. We reported earlier that changes in availability of food - from good to poor or from poor to good - during intrauterine development was followed by a double risk of sudden death as an adult, and that mortality rate can be associated with ancestors' childhood availability of food. We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years' for ancestors of 317 people in Overkalix, Sweden. Results: The confidence intervals were very wide but we found a striking TGR. There was no response in cardiovascular mortality in the grandchild from sharp changes of early exposure, experienced by three of the four grandparents (maternal grandparents and paternal grandfathers). If, however, the paternal grandmother up to puberty lived through a sharp change in food supply from one year to next, her sons' daughters had an excess risk for cardiovascular mortality (HR 2.69, 95% confidence interval 1.05-6.92). Selection or learning and imitation are unlikely explanations. X-linked epigenetic inheritance via spermatozoa seemed to be plausible, with the transmission, limited to being through the father, possibly explained by the sex differences in meiosis. Conclusion: The shock of change in food availability seems to give specific transgenerational responses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Epidemiology
- Food change
- Environmental shock
- Human transgenerational response
- Cardiovascular mortality
- Overkalix
Publication and Content Type
- ref (subject category)
- art (subject category)
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