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The histone deacety...
The histone deacetylases sir2 and rpd3 act on ribosomal DNA to control the replication program in budding yeast
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Yoshida, Kazumasa (author)
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Bacal, Julien (author)
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Desmarais, Damien (author)
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Padioleau, Ismaël (author)
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- Tsaponina, Olga (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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- Chabes, Andrei (author)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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Pantesco, Véronique (author)
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Dubois, Emeric (author)
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Parrinello, Hugues (author)
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Skrzypczak, Magdalena (author)
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Ginalski, Krzysztof (author)
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Lengronne, Armelle (author)
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Pasero, Philippe (author)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 54:4, s. 691-697
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In S. cerevisiae, replication timing is controlled by epigenetic mechanisms restricting the accessibility of origins to limiting initiation factors. About 30% of these origins are located within repetitive DNA sequences such as the ribosomal DNA (rDNA) array, but their regulation is poorly understood. Here, we have investigated how histone deacetylases (HDACs) control the replication program in budding yeast. This analysis revealed that two HDACs, Rpd3 and Sir2, control replication timing in an opposite manner. Whereas Rpd3 delays initiation at late origins, Sir2 is required for the timely activation of early origins. Moreover, Sir2 represses initiation at rDNA origins, whereas Rpd3 counteracts this effect. Remarkably, deletion of SIR2 restored normal replication in rpd3Δ cells by reactivating rDNA origins. Together, these data indicate that HDACs control the replication timing program in budding yeast by modulating the ability of repeated origins to compete with single-copy origins for limiting initiation factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Yoshida, Kazumas ...
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Bacal, Julien
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Desmarais, Damie ...
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Padioleau, Ismaë ...
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Tsaponina, Olga
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Chabes, Andrei
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show more...
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Pantesco, Véroni ...
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Dubois, Emeric
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Parrinello, Hugu ...
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Skrzypczak, Magd ...
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Ginalski, Krzysz ...
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Lengronne, Armel ...
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Pasero, Philippe
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Molecular Cell
- By the university
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Umeå University