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Skin and Plasma Aut...
Skin and Plasma Autofluorescence During Hemodialysis : A Pilot Study
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Graaff, Reindert (author)
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Arsov, Stefan (author)
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- Ramsauer, Bernd (author)
- Umeå universitet,Medicin
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Koetsier, Marten (author)
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- Sundvall, Nils (author)
- Umeå universitet,Medicin,Sunderbyn Research Unit
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Engels, Gerwin E. (author)
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Sikole, Aleksandar (author)
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- Lundberg, Lennart (author)
- Umeå universitet,Medicin
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Rakhorst, Gerhard (author)
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- Stegmayr, Bernd (author)
- Umeå universitet,Medicin
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(creator_code:org_t)
- 2013-10-29
- 2014
- English.
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In: Artificial Organs. - : Wiley. - 0160-564X .- 1525-1594. ; 38:6, s. 515-518
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Skin autofluorescence (AF) is related to the accumulation of advanced glycation end products (AGEs) and is one of the strongest prognostic markers of mortality in hemodialysis (HD) patients. The aim of this pilot study was to investigate whether changes in skin AF appear after a single HD session and if they might be related to changes in plasma AF. Skin and plasma AF were measured before and after HD in 35 patients on maintenance HD therapy (nine women and 26 men, median age 68 years, range 33-83). Median dialysis time was 4h (range 3-5.5). Skin AF was measured noninvasively with an AGE Reader, and plasma AF was measured before and after HD at 460nm after excitation at 370nm. The HD patients had on average a 65% higher skin AF value than age-matched healthy persons (P<0.001). Plasma AF was reduced by 14% (P<0.001), whereas skin AF was not changed after a single HD treatment. No significant influence of the reduced plasma AF on skin AF levels was found. This suggests that the measurement of skin AF can be performed during the whole dialysis period and is not directly influenced by the changes in plasma AF during HD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Hemodialysis
- Skin autofluorescence
- Plasma autofluorescence
- Advanced glycation end products
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Graaff, Reindert
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Arsov, Stefan
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Ramsauer, Bernd
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Koetsier, Marten
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Sundvall, Nils
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Engels, Gerwin E ...
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show more...
-
Sikole, Aleksand ...
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Lundberg, Lennar ...
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Rakhorst, Gerhar ...
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Stegmayr, Bernd
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Artificial Organ ...
- By the university
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Umeå University