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Controlled exposure...
Controlled exposures to air pollutants and risk of cardiac arrhythmia
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- Langrish, Jeremy P. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Watts, Simon J. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Hunter, Amanda J. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Shah, Anoop S. V. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Bosson, Jenny A (author)
- Umeå universitet,Lungmedicin
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- Unosson, Jon (author)
- Umeå universitet,Lungmedicin
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- Barath, Stefan (author)
- Umeå universitet,Lungmedicin
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- Lundbäck, Magnus (author)
- Umeå universitet,Lungmedicin
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- Cassee, Flemming R. (author)
- National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
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- Donaldson, Ken (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Sandström, Thomas (author)
- Umeå universitet,Lungmedicin
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- Blomberg, Anders (author)
- Umeå universitet,Lungmedicin
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- Newby, David E. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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- Mills, Nicholas L. (author)
- University of Edinburgh, University/BHF Centre for Cardiovascular Science, Edinburgh, United Kingdom
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(creator_code:org_t)
- Environmental Health Perspectives, 2014
- 2014
- English.
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In: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 122:7, s. 747-753
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Epidemiological studies have reported associations between air pollution exposure and increases in cardiovascular morbidity and mortality. Exposure to air pollutants can influence cardiac autonomic tone and reduce heart rate variability, and may increase the risk of cardiac arrhythmias, particularly in susceptible patient groups. OBJECTIVES: We investigated the incidence of cardiac arrhythmias during and after controlled exposure to air pollutants in healthy volunteers and patients with coronary heart disease. METHODS: We analyzed data from 13 double-blind randomized crossover studies including 282 participants (140 healthy volunteers and 142 patients with stable coronary heart disease) from whom continuous electrocardiograms were available. The incidence of cardiac arrhythmias was recorded for each exposure and study population. RESULTS: There were no increases in any cardiac arrhythmia during or after exposure to dilute diesel exhaust, wood smoke, ozone, concentrated ambient particles, engineered carbon nanoparticles, or high ambient levels of air pollution in either healthy volunteers or patients with coronary heart disease. CONCLUSIONS: Acute controlled exposure to air pollutants did not increase the short-term risk of arrhythmia in participants. Research employing these techniques remains crucial in identifying the important pathophysiological pathways involved in the adverse effects of air pollution, and is vital to inform environmental and public health policy decisions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Langrish, Jeremy ...
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Watts, Simon J.
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Hunter, Amanda J ...
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Shah, Anoop S. V ...
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Bosson, Jenny A
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Unosson, Jon
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show more...
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Barath, Stefan
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Lundbäck, Magnus
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Cassee, Flemming ...
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Donaldson, Ken
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Sandström, Thoma ...
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Blomberg, Anders
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Newby, David E.
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Mills, Nicholas ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
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Umeå University