Search: onr:"swepub:oai:DiVA.org:umu-93487" >
Long Noncoding RNA ...
Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A
- Article/chapterEnglish2014
Publisher, publication year, extent ...
-
Elsevier BV,2014
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:umu-93487
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93487URI
-
https://doi.org/10.1016/j.molcel.2014.06.031DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation. How demethylating enzymes are targeted to specific genomic loci remains largely unknown. We show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts with both the TCF21 promoter and GADD45A (growth arrest and DNA-damage-inducible, alpha), a regulator of DNA demethylation. GADD45A in turn recruits thymine-DNA glycosylase for base excision repair-mediated demethylation involving oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in the TCF21 promoter by ten-eleven translocation methylcytosine dioxygenase proteins. The results reveal a function of lncRNAs, serving as a genomic address label for GADD45A-mediated demethylation of specific target genes.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Park, Yoon Jung
(author)
-
Lindroth, Anders M.
(author)
-
Schaefer, Andrea
(author)
-
Oakes, Christopher
(author)
-
Weichenhan, Dieter
(author)
-
Lukanova, AnnekatrinUmeå universitet,Patologi(Swepub:umu)anlu0225
(author)
-
Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
-
Risch, Angela
(author)
-
Meister, Michael
(author)
-
Dienemann, Hendrik
(author)
-
Dyckhoff, Gerhard
(author)
-
Herold-Mende, Christel
(author)
-
Grummt, Ingrid
(author)
-
Niehrs, Christof
(author)
-
Plass, Christoph
(author)
-
Umeå universitetPatologi
(creator_code:org_t)
Related titles
-
In:Molecular Cell: Elsevier BV55:4, s. 604-6141097-27651097-4164
Internet link
Find in a library
To the university's database
- By the author/editor
-
Arab, Khelifa
-
Park, Yoon Jung
-
Lindroth, Anders ...
-
Schaefer, Andrea
-
Oakes, Christoph ...
-
Weichenhan, Diet ...
-
show more...
-
Lukanova, Anneka ...
-
Lundin, Eva
-
Risch, Angela
-
Meister, Michael
-
Dienemann, Hendr ...
-
Dyckhoff, Gerhar ...
-
Herold-Mende, Ch ...
-
Grummt, Ingrid
-
Niehrs, Christof
-
Plass, Christoph
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Medical Biotechn ...
- Articles in the publication
-
Molecular Cell
- By the university
-
Umeå University