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High adherence to a...
High adherence to a gluten-free diet in adolescents with screening-detected celiac disease
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- Webb, Charlotta (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Myléus, Anna (author)
- Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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- Norström, Fredrik, 1974- (author)
- Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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- Hammarroth, Solveig (author)
- Norrtalje Hospital, Sweden
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- Högberg, Lotta (author)
- Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Lagerqvist, Carina (author)
- Umeå universitet,Pediatrik,Umeå University, Sweden
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- Rosén, Anna (author)
- Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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- Sandström, Olof (author)
- Umeå universitet,Pediatrik,Umeå University, Sweden
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- Stenhammar, Lars (author)
- Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Ivarsson, Anneli (author)
- Lund University,Lunds universitet,Umeå universitet,Epidemiologi och global hälsa,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Umeå University, Sweden,Lund University, Sweden
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Carlsson, Annelie (author)
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2015
- 2015
- English.
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In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Lippincott Williams & Wilkins. - 0277-2116 .- 1536-4801. ; 60:1, s. 54-59
- Related links:
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http://dx.doi.org/10...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- OBJECTIVES: To evaluate the gluten-free diet (GFD) adherenceafter one year of follow-up in children with screening-detected celiac disease (CD) in a general population. METHODS: A total of 18,325 12 year olds were invited to participate in apopulation-based CD screening (ETICS- Exploring the Iceberg of Celiacs in Sweden), of whom 13,279 participated. In 240 children, CD was detected through elevated anti-tissue transglutaminase antibodies 2 (TG2-IgA) and verified by a small-intestinal biopsy. This sub-study included the 210 children with TG2-IgAevaluated both at the initialbiopsy occasion and at the one-year follow-up. GFD adherence was evaluated by a combination of TG2-IgA measurements and self-reported adherence (n = 193). RESULTS: After one year, 83% (179/210) had normalizedTG2-IgA levels (<5U/mL). Among those who had >50 U/mL at diagnosis,25% (16/63) still had elevated TG2-IgA but for the majority their initial values were more than halved. Most reported a high level ofGFD adherence ('always' 75%(158/193) and 'often' 14%(30/193)), and 75% (145/193) reported always adhereingcombined with normalized TG2-IgA. Although reporting that they were always adherent, 13 (6.7%) had not yet normalized their TG2-IgA levels completely, however, a majority of these initially had the highestTG2-IgA levels. CONCLUSIONS: GFD adherence is high in adolescents with CD detected by screening of the general population of Swedish 12yearolds. Almost all had normalized serology and reported GFD adherenceat the one-year follow-up. However, a few adolescents whoreported GFD adherence still had elevated TG2-IgA levelssuggesting more severe disease and/or non-adherence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- adolescents
- anti-tissue transglutaminase antibodies
- celiac disease
- gluten-free diet
- screening
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Webb, Charlotta
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Myléus, Anna
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Norström, Fredri ...
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Hammarroth, Solv ...
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Högberg, Lotta
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Lagerqvist, Cari ...
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show more...
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Rosén, Anna
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Sandström, Olof
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Stenhammar, Lars
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Ivarsson, Anneli
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Carlsson, Anneli ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- By the university
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Umeå University
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Lund University
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Linköping University