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High adherence to a gluten-free diet in adolescents with screening-detected celiac disease

Webb, Charlotta (author)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
Myléus, Anna (author)
Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
Norström, Fredrik, 1974- (author)
Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
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Hammarroth, Solveig (author)
Norrtalje Hospital, Sweden
Högberg, Lotta (author)
Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
Lagerqvist, Carina (author)
Umeå universitet,Pediatrik,Umeå University, Sweden
Rosén, Anna (author)
Umeå universitet,Epidemiologi och global hälsa,Umeå University, Sweden
Sandström, Olof (author)
Umeå universitet,Pediatrik,Umeå University, Sweden
Stenhammar, Lars (author)
Linköpings universitet,Östergötlands Läns Landsting,Barn- och ungdomskliniken i Norrköping,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
Ivarsson, Anneli (author)
Lund University,Lunds universitet,Umeå universitet,Epidemiologi och global hälsa,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Umeå University, Sweden,Lund University, Sweden
Carlsson, Annelie (author)
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2015
2015
English.
In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - : Lippincott Williams & Wilkins. - 0277-2116 .- 1536-4801. ; 60:1, s. 54-59
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVES: To evaluate the gluten-free diet (GFD) adherenceafter one year of follow-up in children with screening-detected celiac disease (CD) in a general population. METHODS: A total of 18,325 12 year olds were invited to participate in apopulation-based CD screening (ETICS- Exploring the Iceberg of Celiacs in Sweden), of whom 13,279 participated. In 240 children, CD was detected through elevated anti-tissue transglutaminase antibodies 2 (TG2-IgA) and verified by a small-intestinal biopsy. This sub-study included the 210 children with TG2-IgAevaluated both at the initialbiopsy occasion and at the one-year follow-up. GFD adherence was evaluated by a combination of TG2-IgA measurements and self-reported adherence (n = 193). RESULTS: After one year, 83% (179/210) had normalizedTG2-IgA levels (<5U/mL). Among those who had >50 U/mL at diagnosis,25% (16/63) still had elevated TG2-IgA but for the majority their initial values were more than halved. Most reported a high level ofGFD adherence ('always' 75%(158/193) and 'often' 14%(30/193)), and 75% (145/193) reported always adhereingcombined with normalized TG2-IgA. Although reporting that they were always adherent, 13 (6.7%) had not yet normalized their TG2-IgA levels completely, however, a majority of these initially had the highestTG2-IgA levels. CONCLUSIONS: GFD adherence is high in adolescents with CD detected by screening of the general population of Swedish 12yearolds. Almost all had normalized serology and reported GFD adherenceat the one-year follow-up. However, a few adolescents whoreported GFD adherence still had elevated TG2-IgA levelssuggesting more severe disease and/or non-adherence.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

adolescents
anti-tissue transglutaminase antibodies
celiac disease
gluten-free diet
screening

Publication and Content Type

ref (subject category)
art (subject category)

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