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- Ödmark, Inga-Stina,1948-Umeå universitet,Obstetrik och gynekologi (author)
Well-being at onset of hormone replacement therapy : comparison between two continuous combined regimens
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- 2009-08-03
- Informa UK Limited,2004
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-9362
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9362URI
- https://doi.org/10.1080/13697130310001651526DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-66889URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Objectives To compare the effect on well-being of two continuous combined hormone replacement therapies (HRTs) in women starting treatment (‘starters’) and women switching from mainly sequential HRT (‘switchers’). Methods This was a randomized, double-blind, 1-month trial, in which 249 postmenopausal women were treated with either conjugated estrogen plus medroxyprogesterone acetate (CE/MPA 0.625 mg/5 mg) or 17β-estradiol plus norethisterone acetate (E2/NETA 2 mg/1 mg) continuously. Twelve items for measuring climacteric symptoms and well-being were reported daily on a validated symptom scale. Results Women taking CE/MPA reported lower scores for breast tenderness (p = 0.005), depression (p = 0.019), irritability (p = 0.004) and tension (p = 0.048), compared with women taking E2/NETA. Compared with pretreatment, both groups developed side-effects during the first week: breast tenderness, swelling and depression (p < 0.05). Starters, but also switchers, improved in sweats (p < 0.001 and p = 0.030). Compared with pretreatment ratings, switchers reported higher scores for breast tenderness (p < 0.001), depression (p = 0.050) and negative effects on daily life (p < 0.001), whereas starters reported only physical side-effects (p < 0.05). A history of premenstrual syndrome (PMS) predicted high scores for swelling (p = 0.023), depression (p = 0.024), tension (p = 0.009), irritability (p = 0.027), headache (p < 0.001) and negative effects on daily life (p < 0.001). Conclusions CE/MPA 0.625 mg/5 mg is better tolerated than E2/NETA 2 mg/1 mg, and starters react differently from switchers. Side-effects occur more quickly than benefits with HRT, and are more frequent in women with previous PMS.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reproduktionsmedicin och gynekologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Obstetrics, Gynaecology and Reproductive Medicine hsv//eng
- breast/physiopathology
- contraceptive Agents
- female/therapeutic use
- depression/drug therapy/psychology
- double-Blind method
- edema/physiopathology
- estrogen replacement therapy/*methods
- estrogens/therapeutic use
- estrogens
- conjugated (USP)/therapeutic use
- female
- humans
- irritable mood
- medroxyprogesterone 17-acetate/therapeutic use
- middle aged
- norethindrone/*analogs & derivatives/therapeutic use
- pain/physiopathology
- postmenopause/physiology/*psychology
- predictive value of tests
- prospective studies
- quality of life
- sleep initiation and maintenance disorders/drug therapy/psychology
- sweating/drug effects/physiology
- Obstetrics and gynaecology
- Obstetrik och gynekologi
- obstetrik och gynekologi
- Obstetrics and Gynaecology
Added entries (persons, corporate bodies, meetings, titles ...)
- Bäckström, TorbjörnUmeå universitet,Obstetrik och gynekologi(Swepub:umu)toba0001 (author)
- Jonsson, BUppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Tuvemo(Swepub:uu)bjjon425 (author)
- Bixo, MarieUmeå universitet,Obstetrik och gynekologi(Swepub:umu)mabi0001 (author)
- Umeå universitetObstetrik och gynekologi (creator_code:org_t)
Related titles
- In:Climacteric: Informa UK Limited7:1, s. 92-1021369-71371473-0804
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