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Association between...
Association between the intake of alpha-linolenic acid and the risk of CHD
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Vedtofte, Mia Sadowa (author)
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Jakobsen, Marianne U. (author)
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Lauritzen, Lotte (author)
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O'Reilly, Eilis J. (author)
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Virtamo, Jarmo (author)
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Knekt, Paul (author)
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Colditz, Graham (author)
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- Hallmans, Göran (author)
- Umeå universitet,Enheten för biobanksforskning
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Buring, Julie (author)
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Steffen, Lyn M. (author)
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Robien, Kimberly (author)
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Rimm, Eric B. (author)
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Heitmann, Berit L. (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: British Journal of Nutrition. - 0007-1145 .- 1475-2662. ; 112:5, s. 735-743
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The intake of the mainly plant-derived n-3 PUFA alpha-linolenic acid (ALA) has been reported to be associated with a lower risk of CHD. However, the results have been inconsistent. Therefore, the objective of the present study was to examine the association between the intake of ALA and the risk of CHD. Potential effect modification by the intake of long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148 675 women and 80 368 men were used. The outcome measure was incident CHD (CHD event and death). During 4-10 years of follow-up, 4493 CHD events and 1751 CHD deaths occurred. Among men, an inverse association (not significant) between the intake of ALA and the risk of CHD events and deaths was observed. For each additional gram of ALA consumed, a 15% lower risk of CHD events (hazard ratios (HR) 0.85, 95% CI 0.72, 1.01) and a 23% lower risk of CHD deaths (HR 0.77, 95% CI 0.58, 1.01) were observed. No consistent association was observed among women. No effect modification by the intake of n-3 LCPUFA was observed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- alpha-Linolenic acid
- CHD
- Epidemiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vedtofte, Mia Sa ...
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Jakobsen, Marian ...
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Lauritzen, Lotte
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O'Reilly, Eilis ...
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Virtamo, Jarmo
-
Knekt, Paul
-
show more...
-
Colditz, Graham
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Hallmans, Göran
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Buring, Julie
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Steffen, Lyn M.
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Robien, Kimberly
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Rimm, Eric B.
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Heitmann, Berit ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University