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- Gustafsson, ÅsaUmeå universitet,Lungmedicin,FOI (author)
Genetic variation influences immune responses in sensitive rats following exposure to TiO2 nanoparticles
- Article/chapterEnglish2014
Publisher, publication year, extent ...
- Elsevier,2014
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-95723
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-95723URI
- https://doi.org/10.1016/j.tox.2014.10.004DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:130422090URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Forskningsfinansiär: Umeå Center for Environmental Research, and by the Swedish Ministry of Defence
- This study examines the immunological responses in rats following inhalation to titanium dioxide nanoparticles (TiO2 NPs), in naïve rats and in rats with induced allergic airway disease. The responses of two different inbred rat strains were compared: the Dark Aguoti (DA), susceptible to chronic inflammatory disorders, and the Brown Norwegian (BN), susceptible to atopic allergic inflammation. Naïve rats were exposed to an aerosol of TiO2 NPs once daily for 10 days. Another subset of rats was sensitized to the allergen ovalbumin (OVA) in order to induce airway inflammation. These sensitized rats were exposed to TiO2 NPs before and during the allergen challenge. Naïve rats exposed to TiO2 NPs developed an increase of neutrophils and lymphocytes in both rat strains. Airway hyperreactivity and production of inflammatory mediators typical of a T helper 1 type immune response were significantly increased, only in DA rats. Sensitization of the rats induced a prominent OVA-specific-IgE and IgG response in the BN rat while DA rats only showed an increased IgG response. Sensitized rats of both strains developed airway eosinophilia following allergen challenge, which declined upon exposure to TiO2 NPs. The level of neutrophils and lymphocytes increased upon exposure to TiO2 NPs in the airways of DA rats but remained unchanged in the airways of BN rats. In conclusion, the responses to TiO2 NPs were strain-dependent, indicating that genetics play a role in both immune and airway reactivity. DA rats were found to be higher responder compared to BN rats, both when it comes to responses in naïve and sensitized rats. The impact of genetically determined factors influencing the inflammatory reactions pinpoints the complexity of assessing health risks associated with nanoparticle exposures.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Lungmedicin och allergi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Respiratory Medicine and Allergy hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
- Titanium dioxide
- Inflammation
- Asthma
- Ovalbumin
- Aerosol inhalation
- Immune response
- Toxicology
- toxikologi
- Occupational and Environmental Medicine
- arbets- och miljömedicin
- lungmedicin
- Lung Medicine
- nanopartiklar
- nanoparticles
- nanotoxikologi
- nanotoxicology
- immunologi
- Immunology
Added entries (persons, corporate bodies, meetings, titles ...)
- Jonasson, SofiaFOI (author)
- Sandström, ThomasUmeå universitet,Lungmedicin(Swepub:umu)thsa0001 (author)
- Lorentzen, JohnnyKarolinska Institutet (author)
- Bucht, AndersUmeå universitet,Lungmedicin,FOI(Swepub:umu)anbu0006 (author)
- Umeå universitetLungmedicin (creator_code:org_t)
Related titles
- In:Toxicology: Elsevier326, s. 74-850300-483X1879-3185
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