Circulating Estrogen Metabolites and Risk of Breast Cancer in Postmenopausal Women

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:umu-98455" > Circulating Estroge...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Arslan, Alan A. (author)

Circulating Estrogen Metabolites and Risk of Breast Cancer in Postmenopausal Women

Article/chapterEnglish2014

Publisher, publication year, extent ...

2014
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:umu-98455
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-98455URI
https://doi.org/10.1158/1055-9965.EPI-14-0009DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background: It has been hypothesized that predominance of the 2-hydroxylation estrogen metabolism pathway over the 16 alpha-hydroxylation pathway may be inversely associated with breast cancer risk. Methods: We examined the associations of invasive breast cancer risk with circulating 2-hydroxyestrone (2-OHE1), 16 alpha-hydroxyestrone (16 alpha-OHE1), and the 2-OHE1: 16 alpha-OHE1 ratio in a case-control study of postmenopausal women nested within two prospective cohorts: the New York University Women's Health Study (NYUWHS) and the Northern Sweden Mammary Screening Cohort (NSMSC), with adjustment for circulating levels of estrone, and additional analyses by tumor estrogen receptor (ER) status. Levels of 2-OHE1 and 16 alpha-OHE1 were measured using ESTRAMET 2/16 assay in stored serum or plasma samples from 499 incident breast cancer cases and 499 controls, who were matched on cohort, age, and date of blood donation. Results: Overall, no significant associations were observed between breast cancer risk and circulating levels of 2-OHE1, 16 alpha-OHE1, or their ratio in either cohort and in combined analyses. For 2-OHE1, there was evidence of heterogeneity by ER status in models adjusting for estrone (P <= 0.03). We observed a protective association of 2-OHE1 with ER + breast cancer [multivariate-adjusted OR for a doubling of 2-OHE1, 0.67 (95% confidence interval [CI], 0.48-0.94; P = 0.02)]. Conclusions: In this study, higher levels of 2-OHE1 were associated with reduced risk of ER + breast cancer in postmenopausal women after adjustment for circulating estrone. Impact: These results suggest that taking into account the levels of parent estrogens and ER status is important in studies of estrogen metabolites and breast cancer.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

Koenig, Karen L. (author)
Lenner, PerUmeå universitet,Onkologi(Swepub:umu)pele0005 (author)
Afanasyeva, Yelena (author)
Shore, Roy E. (author)
Chen, Yu (author)
Lundin, EvaUmeå universitet,Institutionen för medicinsk biovetenskap(Swepub:umu)evlu0001 (author)
Toniolo, Paolo (author)
Hallmans, GöranUmeå universitet,Enheten för biobanksforskning,Näringsforskning(Swepub:umu)goha0001 (author)
Zeleniuch-Jacquotte, AnneUmeå universitet,Enheten för biobanksforskning (author)
Umeå universitetOnkologi (creator_code:org_t)

Related titles

In:Cancer Epidemiology, Biomarkers and Prevention23:7, s. 1290-12971055-99651538-7755

Internet link

Find in a library

Cancer Epidemiology, Biomarkers and Prevention (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Arslan, Alan A.; Koenig, Karen L.; Lenner, Per; Afanasyeva, Yele ...; Shore, Roy E.; Chen, Yu; show more...; Lundin, Eva; Toniolo, Paolo; Hallmans, Göran; Zeleniuch-Jacquo ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

Articles in the publication: Cancer Epidemiol ...

By the university: Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se