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GRIM REAPER peptide...
GRIM REAPER peptide binds to receptor kinase PRK5 to trigger cell death in Arabidopsis
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Wrzaczek, Michael (author)
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Vainonen, Julia P. (author)
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Stael, Simon (author)
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Tsiatsiani, Liana (author)
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Help-Rinta-Rahko, Hanna (author)
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Gauthier, Adrien (author)
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Kaufholdt, David (author)
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- Bollhöner, Benjamin (author)
- Umeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Centre (UPSC)
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Lamminmaki, Airi (author)
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Staes, An (author)
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Gevaert, Kris (author)
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- Tuominen, Hannele (author)
- Umeå universitet,Institutionen för fysiologisk botanik,Umeå Plant Science Centre (UPSC)
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Van Breusegem, Frank (author)
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Helariutta, Yka (author)
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Kangasjarvi, Jaakko (author)
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(creator_code:org_t)
- 2014-11-14
- 2015
- English.
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In: EMBO Journal. - : EMBO. - 0261-4189 .- 1460-2075. ; 31:1, s. 55-66
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Recognition of extracellular peptides by plasma membrane-localized receptor proteins is commonly used in signal transduction. In plants, very little is known about how extracellular peptides are processed and activated in order to allow recognition by receptors. Here, we show that induction of cell death in planta by a secreted plant protein GRIM REAPER (GRI) is dependent on the activity of the type II metacaspase METACASPASE-9. GRI is cleaved by METACASPASE-9 in vitro resulting in the release of an 11 amino acid peptide. This peptide bound in vivo to the extracellular domain of the plasma membrane-localized, atypical leucine-rich repeat receptor-like kinase POLLEN-SPECIFIC RECEPTOR-LIKE KINASE 5 (PRK5) and was sufficient to induce oxidative stress/ROS-dependent cell death. This shows a signaling pathway in plants from processing and activation of an extracellular protein to recognition by its receptor.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Botanik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Botany (hsv//eng)
Keyword
- ligand
- protease
- receptor-like kinase
- secreted protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wrzaczek, Michae ...
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Vainonen, Julia ...
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Stael, Simon
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Tsiatsiani, Lian ...
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Help-Rinta-Rahko ...
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Gauthier, Adrien
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show more...
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Kaufholdt, David
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Bollhöner, Benja ...
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Lamminmaki, Airi
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Staes, An
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Gevaert, Kris
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Tuominen, Hannel ...
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Van Breusegem, F ...
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Helariutta, Yka
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Kangasjarvi, Jaa ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Botany
- Articles in the publication
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EMBO Journal
- By the university
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Umeå University