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Gramicidin A intera...
Gramicidin A interaction at a dioleoyl phosphatidylcholine monolayer on a mercury drop electrode
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- Lindholm-Sethson, Britta (author)
- Umeå universitet,Kemiska institutionen
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- Nyström, Josefina (author)
- Umeå universitet,Kemiska institutionen
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Geladi, Paul (author)
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Nelson, Andrew (author)
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(creator_code:org_t)
- 2003-01-14
- 2003
- English.
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In: Analytical and Bioanalytical Chemistry. - : Springer Science and Business Media LLC. - 1618-2642. ; 375:3, s. 350-5
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A biosensor where the sensing surface is a fluid dioleyl phosphatidylcholine monolayer (DOPC) deposited on a mercury drop was used. The lipid monolayer was held in 0.1 M NaCl and a concentration of gramicidin A in the range 0-12 nM was used. Electrochemical impedance spectroscopy in the frequency range 0.1-65 kHz was employed to investigate how the defect-free monolayer responds to interactions of gramicidin A in solution.The data was analyzed both with multivariate data analysis and classical electrochemical methods. The principal component analysis of the resulting impedance spectra gave a linear dependence on the concentration of gramicidin A. An increasing permittivity was observed in the low-frequency regime with increasing concentration of gramicidin A in solution.
Keyword
- Phospholipid monolayer
- Gramicidin A
- DOPC
- Impedance spectroscopy
- Multivariate analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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