onr:"swepub:oai:DiVA.org:uu-100546"
Search: onr:"swepub:oai:DiVA.org:uu-100546" > Patterns of Diverge...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Palmé, Anna,1973-Uppsala universitet,Evolutionär funktionsgenomik (author)
Patterns of Divergence among Conifer ESTs and Polymorphism in Pinus sylvestris Identify Putative Selective Sweeps
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2008-08-05
- Oxford University Press (OUP),2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-100546
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100546URI
- https://doi.org/10.1093/molbev/msn194DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Finding genes that are under positive selection is a difficult task, especially in non-model organisms. Here, we haveanalyzed expressed sequence tag (EST) data from 4 species (Pinus pinaster, Pinus taeda, Picea glauca, and Pseudotsugamenziesii) to investigate selection patterns during their evolution and to identify genes likely to be under positiveselection. To confirm selection, population samples of these genes have been sequenced in Pinus sylvestris, a species thatwas not included in the EST data set. The estimates of branch-specific Ka/Ks (nonsynonymous/synonymous substitutionrates) across all genes in the EST data set were similar or smaller than estimates from other higher plant species. Therewas no evidence for the traditional indication of positive selection, Ka/Ks above 1. However, several lines of evidencebased on polymorphism patterns suggest that genes with high Ka/Ks (0.20–0.52) in the EST data set are in fact moreaffected by positive selection in P. sylvestris than genes with low Ka/Ks (0.01–0.04). The high Ka/Ks genes have a lowerlevel of polymorphism and more negative Tajima’s D than the low Ka/Ks genes. Further, in the high Ka/Ks group, theHudson–Kreitman–Aguade test is significant. This suggests that the EST data set is a good starting point for findinggenes under positive selection in conifers and that even moderate Ka/Ks values could be indicative of selection. A groupof 5 genes with high Ka/Ks collectively show evidence for positive selection within P. sylvestris.
Subject headings and genre
- NATURVETENSKAP Biologi Genetik hsv//swe
- NATURAL SCIENCES Biological Sciences Genetics hsv//eng
- selection
- candidate genes
- Ka/Ks
- dn/ds
- Pinus sylvestris
- Scots pine
- Genetics
- Genetik
- Genetics
- genetik
Added entries (persons, corporate bodies, meetings, titles ...)
- Wright, Mark (author)
- Savolainen, Outi (author)
- Uppsala universitetEvolutionär funktionsgenomik (creator_code:org_t)
Related titles
- In:Molecular biology and evolution: Oxford University Press (OUP)25:12, s. 2567-25770737-40381537-1719
Internet link
Find in a library
- Molecular biology and evolution (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Palmé, Anna, 197 ...
- Wright, Mark
- Savolainen, Outi
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Genetics
- Articles in the publication
- Molecular biolog ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
