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Arsenic exposure during pregnancy and size at birth : a prospective cohort study in Bangladesh
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- Rahman, Anisur, 1962- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell barnhälsa och nutrition/Persson
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- Vahter, Marie (author)
- Karolinska Institutet
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Smith, Allan H. (author)
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- Yunus, Mohammed (author)
- ICDDR,B, Bangladesh
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- Arifeen, Shams El (author)
- ICDDR,B, Bangladesh
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- Persson, Lars-Åke (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell barnhälsa och nutrition/Persson
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- Ekström, Eva-Charlotte (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Internationell kvinno- & mödrahälsovård/Essen
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- Nermell, Barbro (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-11-25
- 2009
- English.
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In: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 169:3, s. 304-312
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Abstract
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- The authors evaluated the association of prenatal arsenic exposure with size at birth (birth weight, birth length, head and chest circumferences). This prospective cohort study, based on 1,578 mother-infant pairs, was conducted in Matlab, Bangladesh, in 2002-2003. Arsenic exposure was assessed by analysis of arsenic in urine collected at around gestational weeks 8 and 30. The association of arsenic exposure with size at birth was assessed by linear regression analyses. In analysis over the full range of exposure (6-978 microg/L), no dose-effect association was found with birth size. However, significant negative dose effects were found with birth weight and head and chest circumferences at a low level of arsenic exposure (<100 microg/L in urine). In this range of exposure, birth weight decreased by 1.68 (standard error (SE), 0.62) g for each 1-microg/L increase of arsenic in urine. For head and chest circumferences, the corresponding reductions were 0.05 (SE, 0.03) mm and 0.14 (SE, 0.03) mm per 1 microg/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation.
Keyword
- arsenic
- Bangladesh
- birth weight
- cohort studies
- maternal exposure
- urine
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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