SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-100864"
 

Search: onr:"swepub:oai:DiVA.org:uu-100864" > Sequencing the nucl...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Miller, Webb (author)

Sequencing the nuclear genome of the extinct woolly mammoth.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-100864
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100864URI
  • https://doi.org/10.1038/nature07446DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • In 1994, two independent groups extracted DNA from several Pleistocene epoch mammoths and noted differences among individual specimens. Subsequently, DNA sequences have been published for a number of extinct species. However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused on short mitochondrial sequences, never yielding more than a fraction of a per cent of any nuclear genome. Here we describe 4.17 billion bases (Gb) of sequence from several mammoth specimens, 3.3 billion (80%) of which are from the woolly mammoth (Mammuthus primigenius) genome and thus comprise an extensive set of genome-wide sequence from an extinct species. Our data support earlier reports that elephantid genomes exceed 4 Gb. The estimated divergence rate between mammoth and African elephant is half of that between human and chimpanzee. The observed number of nucleotide differences between two particular mammoths was approximately one-eighth of that between one of them and the African elephant, corresponding to a separation between the mammoths of 1.5-2.0 Myr. The estimated probability that orthologous elephant and mammoth amino acids differ is 0.002, corresponding to about one residue per protein. Differences were discovered between mammoth and African elephant in amino-acid positions that are otherwise invariant over several billion years of combined mammalian evolution. This study shows that nuclear genome sequencing of extinct species can reveal population differences not evident from the fossil record, and perhaps even discover genetic factors that affect extinction.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Drautz, Daniela I (author)
  • Ratan, Aakrosh (author)
  • Pusey, Barbara (author)
  • Qi, Ji (author)
  • Lesk, Arthur M (author)
  • Tomsho, Lynn P (author)
  • Packard, Michael D (author)
  • Zhao, Fangqing (author)
  • Sher, Andrei (author)
  • Tikhonov, Alexei (author)
  • Raney, Brian (author)
  • Patterson, Nick (author)
  • Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)kerli865 (author)
  • Lander, Eric S (author)
  • Knight, James R (author)
  • Irzyk, Gerard P (author)
  • Fredrikson, Karin M (author)
  • Harkins, Timothy T (author)
  • Sheridan, Sharon (author)
  • Pringle, Tom (author)
  • Schuster, Stephan C (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC456:7220, s. 387-3900028-08361476-4687

Internet link

Find in a library

  • Nature (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view