Search: onr:"swepub:oai:DiVA.org:uu-100975" >
Dodecaborate cluste...
Dodecaborate cluster lipids with variable headgroups for boron neutron capture therapy : Synthesis, physical-chemical properties and toxicity
-
Schaffran, Tanja (author)
-
Lizzel, Franziska (author)
-
Samatanga, Brighton (author)
-
show more...
-
- Karlsson, Göran (author)
- Uppsala universitet,Fysikalisk kemi
-
Burghardt, Alexander (author)
-
- Edwards, Katarina (author)
- Uppsala universitet,Fysikalisk kemi
-
Winterhalter, Mathias (author)
-
Peschka-Süss, Regine (author)
-
Schubert, Rolf (author)
-
Gabel, Detlef (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
-
In: Journal of Organometallic Chemistry. - : Elsevier BV. - 0022-328X .- 1872-8561. ; 694:11, s. 1708-1712
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- We have prepared two new boron-containing lipids with potential use in boron neutron capture therapy of tumors. These lipids consist of a diethanolamine frame with two myristoyl chains bonded as esters, and a butylene or ethyleneoxyethylene unit linking the doubly negatively charged dodecaborate cluster to the amino function of the frame, obtained by nucleophilic attack of the amino on the tetrahydrofurane and dioxane derivatives, respectively, of closo-dodecaborate. The latter cluster lipid can form liposomes at 25 °C whereas the former lipid at this temperature assembles into bilayer disks. Both lipids form stable liposomes when mixed with suitable helper lipids. The thermotropic behavior was found to be different for the two lipids, with the butylene lipid showing sharp melting transitions at surprisingly high temperatures. Toxicity in vitro and in vivo varies greatly, with the butylene derivative being more toxic than the ethyleneoxyethylene derivative.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Boron neutron capture therapy
- Boron cluster
- Lipid
- Liposome
- Toxicity
- Chemistry
- Kemi
- Fysikalisk kemi
- Physical Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Schaffran, Tanja
-
Lizzel, Franzisk ...
-
Samatanga, Brigh ...
-
Karlsson, Göran
-
Burghardt, Alexa ...
-
Edwards, Katarin ...
-
show more...
-
Winterhalter, Ma ...
-
Peschka-Süss, Re ...
-
Schubert, Rolf
-
Gabel, Detlef
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
- Articles in the publication
-
Journal of Organ ...
- By the university
-
Uppsala University