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Phytochemical inves...
Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt.
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Ibrahim, Nabaweya Ali (author)
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- El-Seedi, Hesham Rushdey (author)
- Uppsala universitet,Avdelningen för farmakognosi
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Mohammed, Magdy Mostafa Desoky (author)
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(creator_code:org_t)
- Informa UK Limited, 2007
- 2007
- English.
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In: Natural Product Research. - : Informa UK Limited. - 1478-6419 .- 1478-6427. ; 21:10, s. 857-866
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Three phenolic compounds cosmosiin, caffeic acid, and p-coumaric acid were isolated for the first time from the leaves of Cupressus sempervirens L., together with cupressuflavone, amentoflavone, rutin, quercitrin, quercetin, myricitrin. The isolated compounds were identified using (1)H- and (13)C-NMR spectra. The hepatoprotective activity of the MeOH extract was carried out in liver homogenate of normal and CCl(4)-treated rats; a significant decrease in glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, cholesterol level, and triglycerides, while a significant increase in the total protein level, was observed after the oral administration of MeOH extract. The free radical scavenging activity against stable 2,2-diphenyl-2-picrylhydrazyl (DPPH*) was measured for MeOH extract and some of the isolated phenolic compounds in comparison with alpha-tocopherol and butylated hydroxy toluene as standard antioxidants using ESR technique, showed high antioxidant activity for quercetin, rutin, caffeic acid, and p-coumaric acid.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Cupressus sempervirens L
- Cupressaceae
- Phenolic compounds
- Hepatoprotective and Antioxidant activities
- PHARMACY
- FARMACI
Publication and Content Type
- ref (subject category)
- art (subject category)
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