Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

Passante, Lara (author)

Gaspard, Nicolas (author)

Degraeve, Mélanie (author)

De Maertelaer, Viviane (author)

Vanderhaeghen, Pierre (author)

(creator_code:org_t)

The Company of Biologists, 2008
2008
English.
In: Development. - : The Company of Biologists. - 0950-1991 .- 1477-9129. ; 135:19, s. 3281-3290

Related links:: https://dev.biologis...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Abstract Subject headings

Brain structures, whether mature or developing, display a wide diversity of pattern and shape, such as layers, nuclei or segments. The striatum in the mammalian forebrain displays a unique mosaic organization (subdivided into two morphologically and functionally defined neuronal compartments: the matrix and the striosomes) that underlies important functional features of the basal ganglia. Matrix and striosome neurons are generated sequentially during embryonic development, and segregate from each other to form a mosaic of distinct compartments. However, the molecular mechanisms that underlie this time-dependent process of neuronal segregation remain largely unknown. Using a novel organotypic assay, we identified ephrin/Eph family members as guidance cues that regulate matrix/striosome compartmentalization. We found that EphA4 and its ephrin ligands displayed specific temporal patterns of expression and function that play a significant role in the spatial segregation of matrix and striosome neurons. Analysis of the striatal patterning in ephrin A5/EphA4 mutant mice further revealed the requirement of EphA4 signalling for the proper sorting of matrix and striosome neuronal populations in vivo. These data constitute the first identification of genes involved in striatal compartmentalization, and reveal a novel mechanism by which the temporal control of guidance cues enables neuronal segregation, and thereby the generation of complex cellular patterns in the brain.

By the author/editor: Passante, Lara; Gaspard, Nicolas; Degraeve, Mélani ...; Frisén, Jonas; Kullander, Klas; De Maertelaer, V ...; show more...; Vanderhaeghen, P ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.