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Expression of the h...
Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
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- Baecklund, Eva (author)
- Uppsala universitet,Reumatologi
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Natkunam, Yasodha (author)
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- Backlin, Carin (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Iliadou, Anastasia (author)
- Karolinska Institutet
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- Askling, Johan (author)
- Karolinska Institutet
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- Ekbom, Anders (author)
- Karolinska Institutet
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Feltelius, Nils (author)
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- Klareskog, Lars (author)
- Karolinska Institutet
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- Enblad, Gunilla (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,Enheten för onkologi
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Lossos, Izidore S. (author)
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Levy, Ronald (author)
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 141:1, s. 69-72
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Abstract
Subject headings
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- Diffuse large B-cell lymphomas (DLBCL) can be subdivided into germinal centre (GC)-like and non-GC-like subtypes by CD10, BCL6 and MUM1/IRF4 status. We previously reported that patients with severe rheumatoid arthritis (RA) are at increased risk of non-GC DLBCL. This study examined a new GC-marker, human germinal-centre-associated lymphoma (HGAL) protein, in RA-DLBCL. Of 111, 38 (34%) DLBCL were HGAL-positive and showed less disseminated disease and a tendency toward improved overall survival compared to HGAL-negative cases. This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- human germinal-centre-associated protein
- lymphoma
- rheumatoid arthritis
- diffuse large B-cell lymphoma
- B-cells
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Baecklund, Eva
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Natkunam, Yasodh ...
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Backlin, Carin
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Iliadou, Anastas ...
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Askling, Johan
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Ekbom, Anders
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show more...
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Feltelius, Nils
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Klareskog, Lars
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Enblad, Gunilla
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Lossos, Izidore ...
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Levy, Ronald
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Sundström, Chris ...
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Rosenquist, Rich ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Karolinska Institutet