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Serum YKL-40 and in...
Serum YKL-40 and interleukin 6 levels in Hodgkin lymphoma
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Biggar, Robert J. (author)
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Johansen, Julia S. (author)
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- Smedby, Karin Ekström (author)
- Karolinska Institutet
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Rostgaard, Klaus (author)
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Chang, Ellen T. (author)
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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- Glimelius, Bengt (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Molin, Daniel (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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Hamilton-Dutoit, Stephen (author)
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Melbye, Mads (author)
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Hjalgrim, Henrik (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Clinical Cancer Research. - 1078-0432 .- 1557-3265. ; 14:21, s. 6974-8
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- PURPOSE: Serum levels of the inflammatory markers YKL-40 and interleukin 6 (IL-6) are increased in many conditions, including cancers. We examined serum YKL-40 and IL-6 levels in patients with Hodgkin lymphoma, a tumor with strong immunologic reaction to relatively few tumor cells, especially in nodular sclerosis Hodgkin lymphoma. EXPERIMENTAL DESIGN: We analyzed Danish and Swedish patients with incident Hodgkin lymphoma (N=470) and population controls from Denmark (n=245 for YKL-40; n=348 for IL-6). Serum YKL-40 and IL-6 levels were determined by ELISA, and log-transformed data were analyzed by linear regression, adjusting for age and sex. RESULTS: Serum levels of YKL-40 and IL-6 increased in Hodgkin lymphoma patients compared with controls (YKL-40, 3.6-fold; IL-6, 8.3-fold; both, P<0.0001). In pretreatment samples from pretreatment Hodgkin lymphoma patients (n=176), levels were correlated with more advanced stages (P(trend), 0.0001 for YKL-40 and 0.013 for IL-6) and in those with B symptoms; however, levels were similar in nodular sclerosis and mixed cellularity subtypes, by EBV status, and in younger (<45 years old) and older patients. Patients tested soon after treatment onset had significantly lower levels than pretreatment patients; however, even >or=6 months after treatment onset, serum YKL-40 and IL-6 levels remained significantly increased compared with controls. In patients who died (n=12), pretreatment levels for YKL-40 and IL-6 were higher than in survivors, although not statistically significantly. CONCLUSIONS: Serum YKL-40 and IL-6 levels were increased in untreated Hodgkin lymphoma patients and those with more advanced stages but did not differ significantly by Hodgkin lymphoma histology. Following treatment, serum levels were significantly lower.
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- MEDICIN
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- art (subject category)
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Biggar, Robert J ...
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Johansen, Julia ...
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Smedby, Karin Ek ...
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Rostgaard, Klaus
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Chang, Ellen T.
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Adami, Hans-Olov
-
show more...
-
Glimelius, Bengt
-
Molin, Daniel
-
Hamilton-Dutoit, ...
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Melbye, Mads
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Hjalgrim, Henrik
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show less...
- Articles in the publication
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Clinical Cancer ...
- By the university
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Uppsala University
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Karolinska Institutet