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Association of 5-HT...
Association of 5-HTT gene polymorphism, platelet MAO activity, and drive for thinness in a population-based sample of adolescent girls
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Akkermann, Kirsti (author)
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Paaver, Marika (author)
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- Nordquist, Niklas (author)
- Uppsala universitet,Farmakologi
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- Oreland, Lars (author)
- Uppsala universitet,Farmakologi
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Harro, Jaanus (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: International Journal of Eating Disorders. - : Wiley. - 0276-3478 .- 1098-108X. ; 41:5, s. 399-404
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- OBJECTIVE: Several lines of evidence suggest that alterations in serotonergic activity contribute to the pathophysiology of abnormal eating behaviors. Since platelet monoamine oxidase (MAO) activity and the 5-HT transporter gene promoter polymorphism (5-HTTLPR) have been associated with eating disorders, the knowledge from a population-based sample may provide useful information which changes in 5-HT function observed in eating disorders represent trait vs. state effects. METHOD: The sample was based on both cohorts of the Estonian Children Personality, Behavior and Health Study (ECPBHS). The current study was conducted during the second follow-up where altogether 82% from the original sample was recruited. EDI-2 subscales--Drive for Thinness and Bulimia--were used to determine eating attitudes and behaviors. Platelet MAO activity was measured and the participants were genotyped for the 5-HTTLPR. RESULTS: Allelic variation of 5-HTTLPR or platelet MAO activity were not independently associated with drive for thinness or binge eating, but girls homozygous for the 5-HTTLPR long allele and with high platelet MAO activity, both considered indicators of a higher capacity 5-HT system, exhibited higher scores of drive for thinness. CONCLUSION: The results suggest that drive for thinness is the highest in girls with the presence of two markers of higher serotonergic capacity.
Keyword
- 5-HTTLPR
- platelet MAO activity
- drive for thinness
- binge eating; 5-HT
- eating disorders
- adolescents
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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