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Inflammatory mediat...
Inflammatory mediators expressed in human islets of Langerhans : implications for islet transplantation
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- Johansson, Ulrika, 1974- (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,P Magnusson and O Korsgren
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- Olsson, Annika (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Gabrielsson, Susanne (författare)
- Karolinska Institutet
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- Nilsson, Bo (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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- Korsgren, Olle (författare)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 308:3, s. 474-479
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Expression of immune modulating mediators in human Islets of Langerhans could have important implications for development of autoimmunity in type 1 diabetes and influence the outcome of clinical islet transplantation. Islets obtained from five donors were analyzed at various times after isolation using cDNA array technology. The Atlas Human Cytokine/Receptor and Hematology/Immunology nylon membranes representing 268 genes and 406, respectively, were used and the relative expression of each gene analyzed. Of the 51 gene products identified, high mRNA expression of MCP-1, MIF, VEGF, and thymosin beta-10 was detected in all islet samples. IL-8, IL-1-beta, IL-5R, and INF-gamma antagonist were expressed in islets cultured for 2 days. IL-2R was expressed in islets cultured for more than 6 days. In conclusion, several inflammatory mediators were expressed in isolated islets, particularly at an early stage after isolation, indicating that a few days of culture could be beneficial for the outcome of islet transplantation.
Nyckelord
- Islets of Langerhans
- cytokines
- chytokine receptors
- human
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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