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  • Baecklund, EvaUppsala universitet,Reumatologi (author)

Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • 2006
  • Wiley,2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-103048
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103048URI
  • https://doi.org/10.1002/art.22277DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1934527URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE:Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, with a correlation between RA disease severity and lymphoma risk, most pronounced for diffuse large B cell lymphomas (DLBCLs), which also constitute the majority of RA-associated lymphomas. DLBCLs can be further subdivided into germinal center (GC)-like and non-GC-like subtypes, with different cellular origins and prognoses. This study was undertaken to investigate whether RA displays a specific association with any of the DLBCL subtypes.METHODS:We identified 139 patients with DLBCLs within a population-based case-control study of 378 RA patients with lymphoma. The DLBCLs were examined for CD10, Bcl-6, and interferon regulatory factor 4 expression patterns, subclassified into GC and non-GC subtypes, and then correlated with clinical parameters.RESULTS:We found a statistically significant predominance of the non-GC subtype (97 patients; 70% of all DLBCLs). These patients more often had an advanced stage of lymphoma at diagnosis and had a worse 5-year overall survival rate (16% versus 33%) compared with patients with the GC subtype. There was a strong association with RA disease activity in both subtypes, with >70% of the GC and non-GC cases occurring in RA patients with the highest overall disease activity scores.CONCLUSION: These findings suggest that severe RA is particularly associated with the non-GC subtype of DLBCL, and indicate a critical role of activated peripheral B cells as the cells of origin in these lymphomas.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Backlin, CarinUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)kariback (author)
  • Iliadou, AnastasiaKarolinska Institutet (author)
  • Granath, FredrikKarolinska Institutet (author)
  • Ekbom, AndersKarolinska Institutet (author)
  • Amini, Rose-MarieUppsala universitet,Institutionen för genetik och patologi (author)
  • Feltelius, Nils (author)
  • Enblad, GunillaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi (author)
  • Sundström, ChristerUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)chrisund (author)
  • Klareskog, LarsKarolinska Institutet (author)
  • Askling, JohanKarolinska Institutet (author)
  • Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose (author)
  • Uppsala universitetReumatologi (creator_code:org_t)

Related titles

  • In:Arthritis and Rheumatism: Wiley54:12, s. 3774-37810004-35911529-0131

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