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Baecklund, EvaUppsala universitet,Reumatologi
(author)
Characteristics of diffuse large B cell lymphomas in rheumatoid arthritis
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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2006
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Wiley,2006
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-103048
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103048URI
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https://doi.org/10.1002/art.22277DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1934527URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE:Patients with rheumatoid arthritis (RA) are at increased risk of malignant lymphomas, with a correlation between RA disease severity and lymphoma risk, most pronounced for diffuse large B cell lymphomas (DLBCLs), which also constitute the majority of RA-associated lymphomas. DLBCLs can be further subdivided into germinal center (GC)-like and non-GC-like subtypes, with different cellular origins and prognoses. This study was undertaken to investigate whether RA displays a specific association with any of the DLBCL subtypes.METHODS:We identified 139 patients with DLBCLs within a population-based case-control study of 378 RA patients with lymphoma. The DLBCLs were examined for CD10, Bcl-6, and interferon regulatory factor 4 expression patterns, subclassified into GC and non-GC subtypes, and then correlated with clinical parameters.RESULTS:We found a statistically significant predominance of the non-GC subtype (97 patients; 70% of all DLBCLs). These patients more often had an advanced stage of lymphoma at diagnosis and had a worse 5-year overall survival rate (16% versus 33%) compared with patients with the GC subtype. There was a strong association with RA disease activity in both subtypes, with >70% of the GC and non-GC cases occurring in RA patients with the highest overall disease activity scores.CONCLUSION: These findings suggest that severe RA is particularly associated with the non-GC subtype of DLBCL, and indicate a critical role of activated peripheral B cells as the cells of origin in these lymphomas.
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Backlin, CarinUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)kariback
(author)
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Iliadou, AnastasiaKarolinska Institutet
(author)
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Granath, FredrikKarolinska Institutet
(author)
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Ekbom, AndersKarolinska Institutet
(author)
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Amini, Rose-MarieUppsala universitet,Institutionen för genetik och patologi
(author)
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Feltelius, Nils
(author)
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Enblad, GunillaUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
(author)
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Sundström, ChristerUppsala universitet,Molekylär och morfologisk patologi(Swepub:uu)chrisund
(author)
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Klareskog, LarsKarolinska Institutet
(author)
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Askling, JohanKarolinska Institutet
(author)
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Rosenquist, RichardUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)richrose
(author)
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Uppsala universitetReumatologi
(creator_code:org_t)
Related titles
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In:Arthritis and Rheumatism: Wiley54:12, s. 3774-37810004-35911529-0131
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Baecklund, Eva
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Backlin, Carin
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Iliadou, Anastas ...
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Granath, Fredrik
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Ekbom, Anders
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Amini, Rose-Mari ...
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Feltelius, Nils
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Enblad, Gunilla
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Sundström, Chris ...
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Klareskog, Lars
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Askling, Johan
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Rosenquist, Rich ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Arthritis and Rh ...
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Uppsala University
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Karolinska Institutet