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A computerized Infu...
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Eriksson, OlofUppsala universitet,Enheten för radiologi
(author)
A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivo Pharmacokinetic/Pharmacodynamic measurements
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-05-30
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Springer Science and Business Media LLC,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-103237
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103237URI
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https://doi.org/10.1186/1756-6649-8-2DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND:A computer controlled infusion pump (UIPump) for regulation of target tissue concentration of radioactive compounds was developed for use in biological research and tracer development for PET.METHODS:Based on observed tissue or plasma kinetics after a bolus injection of the tracer an algorithm calculates the infusion needed to obtain a specified target kinetic curve. A computer feeds this infusion scheme into an infusion pump connected to an animal via a venous catheter. The concept was validated using [11C]Flumazenil administrated to Sprague-Dawley rats where the whole brain distribution and kinetic of the tracer was measured over time using a microPET-scanner. The accuracy and precision of the system was assessed by producing steady-state levels of the tracer and by mimicking kinetics after oral administration.RESULTS:Various kinetic profiles could be generated, including rapid achievement of constant levels, or step-wise increased levels. The resulting tissue curves had low deviation from the target curves according to the specified criteria: AUC (%): 4.2 +/- 2.8, Maximal deviation (%): 13.6 +/- 5.0 and R2: 0.95 +/- 0.02.CONCLUSION:The UIPump-system is suitable for use in PET-research for assessment of PK/PD properties by simulation of different tracer tissue kinetics in vivo.
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Wallberg, Andreas
(author)
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Syvänen, StinaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Hammarlund-Udenaes(Swepub:uu)stsyv838
(author)
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Josephsson, RaymondUppsala universitet,Klinisk virologi
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Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang
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Bergström, MatsUppsala universitet,Institutionen för farmaceutisk biovetenskap
(author)
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Uppsala universitetEnheten för radiologi
(creator_code:org_t)
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In:BMC Medical Physics: Springer Science and Business Media LLC8:21756-6649
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