Hyperglycemia and stroke mortality: comparison between fasting and 2-h glucose criteria

Hyperglycemia and stroke mortality : comparison between fasting and 2-h glucose criteria

Hyvärinen, Marjukka (author)

Qiao, Qing (author)

Tuomilehto, Jaakko (author)

Laatikainen, Tiina (author)

Heine, Robert J (author)

Stehouwer, Coen D A (author)

Alberti, K George M M (author)

Pyörälä, Kalevi (author)

(creator_code:org_t)

American Diabetes Association, 2009
2009
English.
In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 32:2, s. 348-354

Related links:: http://care.diabetes...; show more...; https://urn.kb.se/re...; https://doi.org/10.2...; https://urn.kb.se/re...; show less...

Abstract Subject headings

OBJECTIVE: We investigated stroke mortality in individuals in different categories of glycemia and compared hazard ratios (HRs) corresponding to a 1-SD increase in 2-h plasma glucose and fasting plasma glucose (FPG) criteria. RESEARCH DESIGN AND METHODS: We examined data from 2-h 75-g oral glucose tolerance tests taken from 13 European cohorts comprising 11,844 (55%) men and 9,862 (45%) women who were followed up for a median of 10.5 years. A multivariate adjusted Cox proportional hazards model was used to estimate HRs for stroke mortality. RESULTS: In men and women without a prior history of diabetes, multivariate adjusted HRs for stroke mortality corresponding to a 1-SD increase in FPG were 1.02 (95% CI 0.83-1.25) and 1.52 (1.22-1.88) and those in 2-h plasma glucose 1.21 (1.06-1.38) and 1.31 (1.06-1.61), respectively. Addition of 2-h plasma glucose to the model with FPG significantly improved prediction of stroke mortality in men (chi2 = 10.12; P = 0.001) but not in women (chi2 = 0.01; P = 0.94), whereas addition of FPG to 2-h plasma glucose improved stroke mortality in women (chi2 = 4.08; P = 0.04) but not in men (chi2 = 3.29; P = 0.07). CONCLUSIONS: Diabetes defined by either FPG or 2-h plasma glucose increases the risk of stroke mortality. In individuals without a history of diabetes, elevated 2-h postchallenge glucose is a better predictor than elevated fasting glucose in men, whereas the latter is better than the former in women.

By the author/editor: Hyvärinen, Marju ...; Qiao, Qing; Tuomilehto, Jaak ...; Laatikainen, Tii ...; Heine, Robert J; Stehouwer, Coen ...; show more...; Alberti, K Georg ...; Pyörälä, Kalevi; Zethelius, Björn; Stegmayr, Birgit ...; show less...

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